| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFTR | LOC100408115 | ENSCJAP00000009011 | ENSCJAP00000068606 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.945 |
| CFTR | PRKAA1 | ENSCJAP00000009011 | ENSCJAP00000013705 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Non-specific serine/threonine protein kinase. | 0.916 |
| CFTR | PRKAA2 | ENSCJAP00000009011 | ENSCJAP00000029269 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Non-specific serine/threonine protein kinase. | 0.914 |
| CFTR | PRKAB1 | ENSCJAP00000009011 | ENSCJAP00000048298 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Protein kinase AMP-activated non-catalytic subunit beta 1. | 0.915 |
| CFTR | PRKACA | ENSCJAP00000009011 | ENSCJAP00000061444 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.945 |
| CFTR | PRKACB | ENSCJAP00000009011 | ENSCJAP00000046709 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.957 |
| CFTR | PRKACG | ENSCJAP00000009011 | ENSCJAP00000077508 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.945 |
| CFTR | PRKAG1 | ENSCJAP00000009011 | ENSCJAP00000038771 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Uncharacterized protein. | 0.904 |
| CFTR | SLC9A3R1 | ENSCJAP00000009011 | ENSCJAP00000027272 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. | 0.994 |
| CFTR | TJP1 | ENSCJAP00000009011 | ENSCJAP00000032151 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | Tight junction protein 1; Belongs to the MAGUK family. | 0.925 |
| LOC100408115 | CFTR | ENSCJAP00000068606 | ENSCJAP00000009011 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.945 |
| LOC100408115 | PRKAA1 | ENSCJAP00000068606 | ENSCJAP00000013705 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase. | 0.923 |
| LOC100408115 | PRKAA2 | ENSCJAP00000068606 | ENSCJAP00000029269 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase. | 0.921 |
| LOC100408115 | PRKACA | ENSCJAP00000068606 | ENSCJAP00000061444 | Uncharacterized protein; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.901 |
| LOC100408115 | PRKACB | ENSCJAP00000068606 | ENSCJAP00000046709 | Uncharacterized protein; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.941 |
| LOC100408115 | PRKACG | ENSCJAP00000068606 | ENSCJAP00000077508 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.901 |
| LOC100408115 | SLC9A3R1 | ENSCJAP00000068606 | ENSCJAP00000027272 | Uncharacterized protein; Belongs to the protein kinase superfamily. | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. | 0.917 |
| PRKAA1 | CFTR | ENSCJAP00000013705 | ENSCJAP00000009011 | Non-specific serine/threonine protein kinase. | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] | 0.916 |
| PRKAA1 | LOC100408115 | ENSCJAP00000013705 | ENSCJAP00000068606 | Non-specific serine/threonine protein kinase. | Uncharacterized protein; Belongs to the protein kinase superfamily. | 0.923 |
| PRKAA1 | PRKAA2 | ENSCJAP00000013705 | ENSCJAP00000029269 | Non-specific serine/threonine protein kinase. | Non-specific serine/threonine protein kinase. | 0.972 |