STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)    
Predicted Functional Partners:
SLC9A3R1
Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.
   
 0.994
PRKACB
cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily.
 
 
 0.957
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily.
 
 
 0.945
LOC100408115
Uncharacterized protein; Belongs to the protein kinase superfamily.
 
 
 0.945
PRKACG
Uncharacterized protein; Belongs to the protein kinase superfamily.
 
 
 0.945
TJP1
Tight junction protein 1; Belongs to the MAGUK family.
     
 0.925
PRKAA1
Non-specific serine/threonine protein kinase.
   
 0.916
PRKAB1
Protein kinase AMP-activated non-catalytic subunit beta 1.
   
 0.915
PRKAA2
Non-specific serine/threonine protein kinase.
   
 0.914
PRKAG1
Uncharacterized protein.
   
  0.904
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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