STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)    
Predicted Functional Partners:
WIF1
Wnt inhibitory factor 1.
    
 0.958
PORCN
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
 0.958
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.954
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
  
 
 0.943
SFRP1
Secreted frizzled-related protein 1.
    
 0.936
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.930
NOTUM
Notum, palmitoleoyl-protein carboxylesterase.
    
 0.929
GPC3
Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
    
 0.925
FZD3
Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.924
SFRP2
Secreted frizzled related protein 2.
    
 0.915
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.