MTDH protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MTDH

Protein LYRIC. (583 aa)

Predicted Functional Partners:

SND1

0.971

NASP

0.605

RASAL2

0.560

AGO2

0.547

PDK1

0.480

ENSCJAP00000075442

0.480

BCCIP

0.477

ENSCJAP00000072778

0.477

ZCRB1

0.470

ENSCJAP00000076168

0.470

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	MTDH	ENSCJAP00000056892	ENSCJAP00000009264	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein LYRIC.	0.547
AGO2	SND1	ENSCJAP00000056892	ENSCJAP00000032645	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.	0.757
BCCIP	MTDH	ENSCJAP00000022772	ENSCJAP00000009264	BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family.	Protein LYRIC.	0.477
ENSCJAP00000072778	MTDH	ENSCJAP00000072778	ENSCJAP00000009264	BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family.	Protein LYRIC.	0.477
ENSCJAP00000075442	MTDH	ENSCJAP00000075442	ENSCJAP00000009264	Integrator complex subunit 1.	Protein LYRIC.	0.480
ENSCJAP00000076168	MTDH	ENSCJAP00000076168	ENSCJAP00000009264	RRM domain-containing protein.	Protein LYRIC.	0.470
ENSCJAP00000076168	RASAL2	ENSCJAP00000076168	ENSCJAP00000050612	RRM domain-containing protein.	Ras GTPase-activating protein nGAP isoform 2.	0.467
MTDH	AGO2	ENSCJAP00000009264	ENSCJAP00000056892	Protein LYRIC.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.547
MTDH	BCCIP	ENSCJAP00000009264	ENSCJAP00000022772	Protein LYRIC.	BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family.	0.477
MTDH	ENSCJAP00000072778	ENSCJAP00000009264	ENSCJAP00000072778	Protein LYRIC.	BRCA2 and CDKN1A-interacting protein; May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ); Belongs to the BCP1 family.	0.477
MTDH	ENSCJAP00000075442	ENSCJAP00000009264	ENSCJAP00000075442	Protein LYRIC.	Integrator complex subunit 1.	0.480
MTDH	ENSCJAP00000076168	ENSCJAP00000009264	ENSCJAP00000076168	Protein LYRIC.	RRM domain-containing protein.	0.470
MTDH	NASP	ENSCJAP00000009264	ENSCJAP00000025187	Protein LYRIC.	Uncharacterized protein.	0.605
MTDH	PDK1	ENSCJAP00000009264	ENSCJAP00000013979	Protein LYRIC.	Protein-serine/threonine kinase.	0.480
MTDH	RASAL2	ENSCJAP00000009264	ENSCJAP00000050612	Protein LYRIC.	Ras GTPase-activating protein nGAP isoform 2.	0.560
MTDH	SND1	ENSCJAP00000009264	ENSCJAP00000032645	Protein LYRIC.	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.	0.971
MTDH	ZCRB1	ENSCJAP00000009264	ENSCJAP00000032747	Protein LYRIC.	Zinc finger CCHC-type and RNA-binding motif-containing protein 1.	0.470
NASP	MTDH	ENSCJAP00000025187	ENSCJAP00000009264	Uncharacterized protein.	Protein LYRIC.	0.605
PDK1	MTDH	ENSCJAP00000013979	ENSCJAP00000009264	Protein-serine/threonine kinase.	Protein LYRIC.	0.480
RASAL2	ENSCJAP00000076168	ENSCJAP00000050612	ENSCJAP00000076168	Ras GTPase-activating protein nGAP isoform 2.	RRM domain-containing protein.	0.467