Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GCGGlucagon. (263 aa)    
Predicted Functional Partners:
GLP1R
Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.996
GLP2R
Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.989
GCGR
Glucagon receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.981
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
   
 
 0.955
GIPR
Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.942
GHRL
Appetite-regulating hormone isoform 1 preproprotein.
   
 
 0.931
GPR119
G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family.
     
 0.909
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
     
 0.882
DPP4
Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.
 
  
 0.868
SST
Somatostatin preproprotein.
   
  
 0.854
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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