| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACLY | ACO2 | ENSCJAP00000027756 | ENSCJAP00000009236 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aconitase 2. | 0.979 |
| ACLY | CS | ENSCJAP00000027756 | ENSCJAP00000020819 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase; Belongs to the citrate synthase family. | 0.997 |
| ACLY | DLST | ENSCJAP00000027756 | ENSCJAP00000038208 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.816 |
| ACLY | FH | ENSCJAP00000027756 | ENSCJAP00000031992 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fumarate hydratase, mitochondrial. | 0.774 |
| ACLY | GOT2 | ENSCJAP00000027756 | ENSCJAP00000020763 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Aspartate aminotransferase. | 0.845 |
| ACLY | IDH2 | ENSCJAP00000027756 | ENSCJAP00000017348 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.842 |
| ACLY | MDH1B | ENSCJAP00000027756 | ENSCJAP00000010955 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Malate dehydrogenase 1B. | 0.704 |
| ACLY | PDHB | ENSCJAP00000027756 | ENSCJAP00000036682 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.627 |
| ACLY | PKLR | ENSCJAP00000027756 | ENSCJAP00000048105 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.503 |
| ACLY | SUCLG1 | ENSCJAP00000027756 | ENSCJAP00000036845 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.970 |
| ACO2 | ACLY | ENSCJAP00000009236 | ENSCJAP00000027756 | Aconitase 2. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.979 |
| ACO2 | CS | ENSCJAP00000009236 | ENSCJAP00000020819 | Aconitase 2. | Citrate synthase; Belongs to the citrate synthase family. | 0.998 |
| ACO2 | DLST | ENSCJAP00000009236 | ENSCJAP00000038208 | Aconitase 2. | 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase). | 0.898 |
| ACO2 | FH | ENSCJAP00000009236 | ENSCJAP00000031992 | Aconitase 2. | Fumarate hydratase, mitochondrial. | 0.798 |
| ACO2 | GOT2 | ENSCJAP00000009236 | ENSCJAP00000020763 | Aconitase 2. | Aspartate aminotransferase. | 0.618 |
| ACO2 | IDH2 | ENSCJAP00000009236 | ENSCJAP00000017348 | Aconitase 2. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.993 |
| ACO2 | MDH1B | ENSCJAP00000009236 | ENSCJAP00000010955 | Aconitase 2. | Malate dehydrogenase 1B. | 0.685 |
| ACO2 | PDHB | ENSCJAP00000009236 | ENSCJAP00000036682 | Aconitase 2. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.793 |
| ACO2 | PKLR | ENSCJAP00000009236 | ENSCJAP00000048105 | Aconitase 2. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.515 |
| ACO2 | SUCLG1 | ENSCJAP00000009236 | ENSCJAP00000036845 | Aconitase 2. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.879 |