STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AIM2Absent in melanoma 2. (351 aa)    
Predicted Functional Partners:
CASP1
Uncharacterized protein; Belongs to the peptidase C14A family.
   
 0.953
TP53BP1
Tumor protein p53 binding protein 1.
    
 0.932
ENSCJAP00000073487
Uncharacterized protein.
    
 0.926
MEFV
Pyrin domain-containing protein.
    
 0.920
NLRP1
NLR family pyrin domain containing 1.
   
 
 0.916
NLRP6
NLR family pyrin domain containing 6.
   
 
 0.847
IL18
Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.
      
 0.752
GSDMD
Gasdermin D.
      
 0.696
CGAS
Cyclic GMP-AMP synthase.
    
 
 0.689
DDX58
Putative ATP-dependent RNA helicase DDX58.
   
  
 0.672
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.