Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IGF1RTyrosine-protein kinase receptor. (1366 aa)    
Predicted Functional Partners:
IGF1
Insulin like growth factor 1.
    
 0.999
IRS1
Insulin receptor substrate 1.
   
 0.998
INSR
Tyrosine-protein kinase receptor.
  
0.997
IGF2
Insulin like growth factor 2.
    
 0.997
GRB10
Growth factor receptor bound protein 10.
    
 0.996
SHC1
SHC-transforming protein 1 isoform 3.
    
 0.995
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.994
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1.
    
 0.989
IRS2
Insulin receptor substrate 2.
   
 0.989
PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma.
    
 0.984
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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