IGF1R protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IGF1R

Tyrosine-protein kinase receptor. (1366 aa)

Predicted Functional Partners:

IGF1

0.999

IGF2

0.999

IRS1

0.998

INS

0.996

GRB10

0.993

SHC1

0.992

INSR

0.986

EGF

0.979

SHC3

0.976

IRS4

0.975

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGF	IGF1	ENSCJAP00000007289	ENSCJAP00000056775	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin like growth factor 1.	0.984
EGF	IGF1R	ENSCJAP00000007289	ENSCJAP00000011684	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase receptor.	0.979
EGF	IGF2	ENSCJAP00000007289	ENSCJAP00000072301	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin like growth factor 2.	0.438
EGF	INS	ENSCJAP00000007289	ENSCJAP00000034117	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.992
EGF	INSR	ENSCJAP00000007289	ENSCJAP00000053402	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase receptor.	0.946
EGF	SHC1	ENSCJAP00000007289	ENSCJAP00000016965	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	SHC-transforming protein 1 isoform 3.	0.663
EGF	SHC3	ENSCJAP00000007289	ENSCJAP00000061495	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	SHC adaptor protein 3.	0.532
GRB10	IGF1	ENSCJAP00000020517	ENSCJAP00000056775	Growth factor receptor bound protein 10.	Insulin like growth factor 1.	0.645
GRB10	IGF1R	ENSCJAP00000020517	ENSCJAP00000011684	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.993
GRB10	IGF2	ENSCJAP00000020517	ENSCJAP00000072301	Growth factor receptor bound protein 10.	Insulin like growth factor 2.	0.640
GRB10	INS	ENSCJAP00000020517	ENSCJAP00000034117	Growth factor receptor bound protein 10.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.515
GRB10	INSR	ENSCJAP00000020517	ENSCJAP00000053402	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.989
GRB10	IRS1	ENSCJAP00000020517	ENSCJAP00000071868	Growth factor receptor bound protein 10.	Insulin receptor substrate 1.	0.621
GRB10	SHC1	ENSCJAP00000020517	ENSCJAP00000016965	Growth factor receptor bound protein 10.	SHC-transforming protein 1 isoform 3.	0.420
GRB10	SHC3	ENSCJAP00000020517	ENSCJAP00000061495	Growth factor receptor bound protein 10.	SHC adaptor protein 3.	0.420
IGF1	EGF	ENSCJAP00000056775	ENSCJAP00000007289	Insulin like growth factor 1.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.984
IGF1	GRB10	ENSCJAP00000056775	ENSCJAP00000020517	Insulin like growth factor 1.	Growth factor receptor bound protein 10.	0.645
IGF1	IGF1R	ENSCJAP00000056775	ENSCJAP00000011684	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.999
IGF1	IGF2	ENSCJAP00000056775	ENSCJAP00000072301	Insulin like growth factor 1.	Insulin like growth factor 2.	0.976
IGF1	INS	ENSCJAP00000056775	ENSCJAP00000034117	Insulin like growth factor 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.993