ETAA1 protein (Callithrix jacchus) - STRING interaction network

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Score

ETAA1

ETAA1 activator of ATR kinase. (893 aa)

Predicted Functional Partners:

RPA1

0.867

ATRIP

0.801

ATR

0.787

BRCA1

0.746

RPA2

0.737

ENSCJAP00000073535

0.737

TUBGCP5

0.731

TUBGCP4

0.685

RPA3

0.672

NEDD1

0.664

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATR	ATRIP	ENSCJAP00000003355	ENSCJAP00000005270	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ATR-interacting protein isoform 1.	0.999
ATR	BRCA1	ENSCJAP00000003355	ENSCJAP00000023883	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.996
ATR	ENSCJAP00000073535	ENSCJAP00000003355	ENSCJAP00000073535	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RPA_C domain-containing protein.	0.838
ATR	ETAA1	ENSCJAP00000003355	ENSCJAP00000012196	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ETAA1 activator of ATR kinase.	0.787
ATR	RPA1	ENSCJAP00000003355	ENSCJAP00000003336	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.925
ATR	RPA2	ENSCJAP00000003355	ENSCJAP00000055184	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	RPA_C domain-containing protein.	0.838
ATR	RPA3	ENSCJAP00000003355	ENSCJAP00000001211	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A 14 kDa subunit.	0.604
ATRIP	ATR	ENSCJAP00000005270	ENSCJAP00000003355	ATR-interacting protein isoform 1.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.999
ATRIP	BRCA1	ENSCJAP00000005270	ENSCJAP00000023883	ATR-interacting protein isoform 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.964
ATRIP	ENSCJAP00000073535	ENSCJAP00000005270	ENSCJAP00000073535	ATR-interacting protein isoform 1.	RPA_C domain-containing protein.	0.850
ATRIP	ETAA1	ENSCJAP00000005270	ENSCJAP00000012196	ATR-interacting protein isoform 1.	ETAA1 activator of ATR kinase.	0.801
ATRIP	RPA1	ENSCJAP00000005270	ENSCJAP00000003336	ATR-interacting protein isoform 1.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.979
ATRIP	RPA2	ENSCJAP00000005270	ENSCJAP00000055184	ATR-interacting protein isoform 1.	RPA_C domain-containing protein.	0.850
ATRIP	RPA3	ENSCJAP00000005270	ENSCJAP00000001211	ATR-interacting protein isoform 1.	Replication protein A 14 kDa subunit.	0.825
BRCA1	ATR	ENSCJAP00000023883	ENSCJAP00000003355	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.996
BRCA1	ATRIP	ENSCJAP00000023883	ENSCJAP00000005270	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR-interacting protein isoform 1.	0.964
BRCA1	ENSCJAP00000073535	ENSCJAP00000023883	ENSCJAP00000073535	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RPA_C domain-containing protein.	0.574
BRCA1	ETAA1	ENSCJAP00000023883	ENSCJAP00000012196	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ETAA1 activator of ATR kinase.	0.746
BRCA1	RPA1	ENSCJAP00000023883	ENSCJAP00000003336	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.956
BRCA1	RPA2	ENSCJAP00000023883	ENSCJAP00000055184	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RPA_C domain-containing protein.	0.574