STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
MCOLN3Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-lin [...] (553 aa)    
Predicted Functional Partners:
MCOLN2
Mucolipin 2.
  
 
 
0.980
MCOLN1
Mucolipin 1.
  
 
0.970
TRPV6
Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.762
NUDT9
ADP-ribose pyrophosphatase, mitochondrial isoform a.
     
 0.719
TRPV2
Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.675
TRPM3
Transient receptor potential cation channel subfamily M member 3 isoform k.
   
 
 0.639
TRPM1
Transient receptor potential cation channel subfamily M member 1.
   
 
 0.621
ARL8B
ADP-ribosylation factor-like protein 8B; Belongs to the small GTPase superfamily. Arf family.
      
 0.620
TRPM5
Transient receptor potential cation channel subfamily M member 5.
   
 
 0.587
TRPV1
Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.559
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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