P3H3 protein (Callithrix jacchus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

P3H3

Fe2OG dioxygenase domain-containing protein. (739 aa)

Predicted Functional Partners:

TSPAN31

0.774

DCUN1D3

0.774

DCBLD1

0.774

ZCCHC14

0.771

DPAGT1

0.770

IRF2BP2

0.770

PPIB

0.756

P3H4

0.712

CRTAP

0.707

EFHC1

0.702

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRTAP	P3H3	ENSCJAP00000021991	ENSCJAP00000014043	Cartilage-associated protein.	Fe2OG dioxygenase domain-containing protein.	0.707
CRTAP	PPIB	ENSCJAP00000021991	ENSCJAP00000009124	Cartilage-associated protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.859
DCBLD1	DCUN1D3	ENSCJAP00000061184	ENSCJAP00000017133	Discoidin, CUB and LCCL domain containing 1.	DCN1-like protein.	0.774
DCBLD1	DPAGT1	ENSCJAP00000061184	ENSCJAP00000025590	Discoidin, CUB and LCCL domain containing 1.	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	0.770
DCBLD1	EFHC1	ENSCJAP00000061184	ENSCJAP00000061309	Discoidin, CUB and LCCL domain containing 1.	EF-hand domain-containing protein 1 isoform 1.	0.702
DCBLD1	IRF2BP2	ENSCJAP00000061184	ENSCJAP00000033570	Discoidin, CUB and LCCL domain containing 1.	Interferon regulatory factor 2 binding protein 2.	0.778
DCBLD1	P3H3	ENSCJAP00000061184	ENSCJAP00000014043	Discoidin, CUB and LCCL domain containing 1.	Fe2OG dioxygenase domain-containing protein.	0.774
DCBLD1	TSPAN31	ENSCJAP00000061184	ENSCJAP00000012543	Discoidin, CUB and LCCL domain containing 1.	Tetraspanin-31; Belongs to the tetraspanin (TM4SF) family.	0.775
DCBLD1	ZCCHC14	ENSCJAP00000061184	ENSCJAP00000064619	Discoidin, CUB and LCCL domain containing 1.	Zinc finger CCHC-type containing 14.	0.771
DCUN1D3	DCBLD1	ENSCJAP00000017133	ENSCJAP00000061184	DCN1-like protein.	Discoidin, CUB and LCCL domain containing 1.	0.774
DCUN1D3	DPAGT1	ENSCJAP00000017133	ENSCJAP00000025590	DCN1-like protein.	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	0.770
DCUN1D3	EFHC1	ENSCJAP00000017133	ENSCJAP00000061309	DCN1-like protein.	EF-hand domain-containing protein 1 isoform 1.	0.702
DCUN1D3	IRF2BP2	ENSCJAP00000017133	ENSCJAP00000033570	DCN1-like protein.	Interferon regulatory factor 2 binding protein 2.	0.770
DCUN1D3	P3H3	ENSCJAP00000017133	ENSCJAP00000014043	DCN1-like protein.	Fe2OG dioxygenase domain-containing protein.	0.774
DCUN1D3	TSPAN31	ENSCJAP00000017133	ENSCJAP00000012543	DCN1-like protein.	Tetraspanin-31; Belongs to the tetraspanin (TM4SF) family.	0.774
DCUN1D3	ZCCHC14	ENSCJAP00000017133	ENSCJAP00000064619	DCN1-like protein.	Zinc finger CCHC-type containing 14.	0.771
DPAGT1	DCBLD1	ENSCJAP00000025590	ENSCJAP00000061184	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	Discoidin, CUB and LCCL domain containing 1.	0.770
DPAGT1	DCUN1D3	ENSCJAP00000025590	ENSCJAP00000017133	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	DCN1-like protein.	0.770
DPAGT1	EFHC1	ENSCJAP00000025590	ENSCJAP00000061309	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	EF-hand domain-containing protein 1 isoform 1.	0.620
DPAGT1	IRF2BP2	ENSCJAP00000025590	ENSCJAP00000033570	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase.	Interferon regulatory factor 2 binding protein 2.	0.731

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.893

expected number of edges:

10

PPI enrichment p-value:

0.0337

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005223

Intracellular cGMP-activated cation channel activity

2 of 7

2.68

1.1

0.0101

GO:0005222

Intracellular cAMP-activated cation channel activity

2 of 9

2.57

1.09

0.0101

GO:0030553

cGMP binding

2 of 16

2.32

1.05

0.0117

GO:0015106

Bicarbonate transmembrane transporter activity

2 of 19

2.25

0.99

0.0146

GO:0099094

Ligand-gated cation channel activity

3 of 109

1.67

0.96

0.0109

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.14

0.0088

GO:0036126

Sperm flagellum

3 of 98

1.71

0.9

0.0164

GO:0097225

Sperm midpiece

2 of 29

2.07

0.72

0.0459

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24164424

(2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.

5 of 14

2.78

4.63

2.08e-09

PMID:33362798

(2020) Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System.

4 of 13

2.72

3.35

5.66e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19067

Mixed, incl. Bicarbonate transporters, and Ral GTPase-activating protein subunit alpha/beta, N-terminal domain

3 of 17

2.47

1.71

0.00069

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 11007

0.23

0.22

0.0282

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017071

Intracellular cyclic nucleotide activated cation channel complex

2 of 5

2.83

1.09

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0406

Ion transport

4 of 286

1.37

0.97

0.0051

KW-0813

Transport

5 of 615

1.14

0.83

0.0051

KW-0407

Ion channel

3 of 198

1.41

0.77

0.0207

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000595

Cyclic nucleotide-binding domain

3 of 26

2.29

1.34

0.0032

IPR018490

Cyclic nucleotide-binding domain superfamily

3 of 29

2.24

1.33

0.0032

IPR014710

RmlC-like jelly roll fold

3 of 37

2.14

1.31

0.0032

IPR032406

Cyclic nucleotide-gated channel, C-terminal leucine zipper domain

2 of 4

2.93

1.2

0.0069

IPR018488

Cyclic nucleotide-binding, conserved site

2 of 13

2.42

0.82

0.0319

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00100

Cyclic nucleotide-monophosphate binding domain

3 of 26

2.29

1.78

0.00042

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