MCOLN1 protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MCOLN1

Mucolipin 1. (580 aa)

Predicted Functional Partners:

MCOLN2

0.973

MCOLN3

0.970

TFEB

0.864

ATP6V1H

0.834

TFE3

0.792

USH1C

0.691

CTSA

0.592

LY6D

0.592

TRPC1

0.580

PITPNB

0.561

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6V1H	CTSA	ENSCJAP00000026684	ENSCJAP00000072997	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.434
ATP6V1H	MCOLN1	ENSCJAP00000026684	ENSCJAP00000015617	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	Mucolipin 1.	0.834
ATP6V1H	TFE3	ENSCJAP00000026684	ENSCJAP00000004707	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	Transcription factor E3.	0.654
ATP6V1H	TFEB	ENSCJAP00000026684	ENSCJAP00000004715	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	BHLH domain-containing protein.	0.735
CTSA	ATP6V1H	ENSCJAP00000072997	ENSCJAP00000026684	Carboxypeptidase; Belongs to the peptidase S10 family.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.434
CTSA	MCOLN1	ENSCJAP00000072997	ENSCJAP00000015617	Carboxypeptidase; Belongs to the peptidase S10 family.	Mucolipin 1.	0.592
CTSA	TFEB	ENSCJAP00000072997	ENSCJAP00000004715	Carboxypeptidase; Belongs to the peptidase S10 family.	BHLH domain-containing protein.	0.554
LY6D	MCOLN1	ENSCJAP00000076933	ENSCJAP00000015617	UPAR/Ly6 domain-containing protein.	Mucolipin 1.	0.592
LY6D	MCOLN3	ENSCJAP00000076933	ENSCJAP00000012762	UPAR/Ly6 domain-containing protein.	Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-lin [...]	0.404
MCOLN1	ATP6V1H	ENSCJAP00000015617	ENSCJAP00000026684	Mucolipin 1.	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.	0.834
MCOLN1	CTSA	ENSCJAP00000015617	ENSCJAP00000072997	Mucolipin 1.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.592
MCOLN1	LY6D	ENSCJAP00000015617	ENSCJAP00000076933	Mucolipin 1.	UPAR/Ly6 domain-containing protein.	0.592
MCOLN1	MCOLN2	ENSCJAP00000015617	ENSCJAP00000012690	Mucolipin 1.	Mucolipin 2.	0.973
MCOLN1	MCOLN3	ENSCJAP00000015617	ENSCJAP00000012762	Mucolipin 1.	Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (By similarity). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-lin [...]	0.970
MCOLN1	PITPNB	ENSCJAP00000015617	ENSCJAP00000037487	Mucolipin 1.	Phosphatidylinositol transfer protein beta.	0.561
MCOLN1	TFE3	ENSCJAP00000015617	ENSCJAP00000004707	Mucolipin 1.	Transcription factor E3.	0.792
MCOLN1	TFEB	ENSCJAP00000015617	ENSCJAP00000004715	Mucolipin 1.	BHLH domain-containing protein.	0.864
MCOLN1	TRPC1	ENSCJAP00000015617	ENSCJAP00000003146	Mucolipin 1.	Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family.	0.580
MCOLN1	USH1C	ENSCJAP00000015617	ENSCJAP00000017142	Mucolipin 1.	USH1 protein network component harmonin.	0.691
MCOLN2	MCOLN1	ENSCJAP00000012690	ENSCJAP00000015617	Mucolipin 2.	Mucolipin 1.	0.973