STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB1Retinoblastoma-associated protein. (927 aa)    
Predicted Functional Partners:
E2F1
E2F transcription factor 1.
   
 0.999
CCNA2
Cyclin-A2; Belongs to the cyclin family.
   
 0.993
E2F3
E2F transcription factor 3.
   
 0.993
CDK4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.993
CCND1
Cyclin D1; Belongs to the cyclin family.
    
 0.993
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
   
 0.991
CCNE1
G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.990
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.990
CCNA1
Cyclin A1; Belongs to the cyclin family.
   
 0.989
SKP2
S-phase kinase associated protein 2.
   
 0.984
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.