Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1281 aa)    
Predicted Functional Partners:
MAP2K6
Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
0.980
MAP2K3
Dual specificity mitogen-activated protein kinase kinase 3 isoform B; Belongs to the protein kinase superfamily.
    
0.980
MAP2K4
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.816
MAP3K5
Mitogen-activated protein kinase kinase kinase 5.
    
   0.769
DAXX
Death domain-associated protein 6 isoform a.
    
 
 0.755
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 
 0.736
PLEKHF1
Pleckstrin homology and FYVE domain containing 1.
      
 0.700
TXNDC2
Thioredoxin domain containing 2.
    
 0.699
LOC108587771
Thioredoxin domain-containing protein.
    
 0.699
TXN
Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]
    
 0.699
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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