STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1999 aa)    
Predicted Functional Partners:
SCN1B
Sodium voltage-gated channel beta subunit 1.
   
 0.990
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.986
SCN4B
Sodium voltage-gated channel beta subunit 4.
    
 0.979
SCN7A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  
 
0.918
PRKACB
cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily.
     
 0.916
F7HBH1_CALJA
Protein kinase domain-containing protein.
   
 0.913
CAMK2D
Protein kinase domain-containing protein.
   
 0.913
CAMK2B
Calcium/calmodulin dependent protein kinase II beta.
   
 0.911
CAMK2A
Calcium/calmodulin dependent protein kinase II alpha.
   
 0.911
PRKACA
cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily.
     
 0.910
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.