SLC22A13 protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SLC22A13

Solute carrier family 22 member 13. (551 aa)

Predicted Functional Partners:

SLC16A5

0.652

PDZK1

0.633

XYLB

0.557

SLC2A2

0.549

SLC34A1

0.541

SLC2A9

0.539

ABCG2

0.507

ACYP2

0.504

SLC22A18

0.490

ENSCJAP00000075442

0.480

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG2	SLC22A13	ENSCJAP00000011839	ENSCJAP00000018717	ATP-binding cassette sub-family G member 2 isoform 1.	Solute carrier family 22 member 13.	0.507
ABCG2	SLC2A9	ENSCJAP00000011839	ENSCJAP00000056088	ATP-binding cassette sub-family G member 2 isoform 1.	Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.637
ACYP2	SLC16A5	ENSCJAP00000057381	ENSCJAP00000026876	Acylphosphatase.	Solute carrier family 16 member 5.	0.826
ACYP2	SLC22A13	ENSCJAP00000057381	ENSCJAP00000018717	Acylphosphatase.	Solute carrier family 22 member 13.	0.504
ENSCJAP00000075442	SLC22A13	ENSCJAP00000075442	ENSCJAP00000018717	Integrator complex subunit 1.	Solute carrier family 22 member 13.	0.480
PDZK1	SLC22A13	ENSCJAP00000004247	ENSCJAP00000018717	Uncharacterized protein.	Solute carrier family 22 member 13.	0.633
PDZK1	SLC34A1	ENSCJAP00000004247	ENSCJAP00000012722	Uncharacterized protein.	Solute carrier family 34 member 1.	0.516
SLC16A5	ACYP2	ENSCJAP00000026876	ENSCJAP00000057381	Solute carrier family 16 member 5.	Acylphosphatase.	0.826
SLC16A5	SLC22A13	ENSCJAP00000026876	ENSCJAP00000018717	Solute carrier family 16 member 5.	Solute carrier family 22 member 13.	0.652
SLC16A5	SLC2A2	ENSCJAP00000026876	ENSCJAP00000004395	Solute carrier family 16 member 5.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.436
SLC22A13	ABCG2	ENSCJAP00000018717	ENSCJAP00000011839	Solute carrier family 22 member 13.	ATP-binding cassette sub-family G member 2 isoform 1.	0.507
SLC22A13	ACYP2	ENSCJAP00000018717	ENSCJAP00000057381	Solute carrier family 22 member 13.	Acylphosphatase.	0.504
SLC22A13	ENSCJAP00000075442	ENSCJAP00000018717	ENSCJAP00000075442	Solute carrier family 22 member 13.	Integrator complex subunit 1.	0.480
SLC22A13	PDZK1	ENSCJAP00000018717	ENSCJAP00000004247	Solute carrier family 22 member 13.	Uncharacterized protein.	0.633
SLC22A13	SLC16A5	ENSCJAP00000018717	ENSCJAP00000026876	Solute carrier family 22 member 13.	Solute carrier family 16 member 5.	0.652
SLC22A13	SLC22A18	ENSCJAP00000018717	ENSCJAP00000077022	Solute carrier family 22 member 13.	Solute carrier family 22 member 18.	0.490
SLC22A13	SLC2A2	ENSCJAP00000018717	ENSCJAP00000004395	Solute carrier family 22 member 13.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.549
SLC22A13	SLC2A9	ENSCJAP00000018717	ENSCJAP00000056088	Solute carrier family 22 member 13.	Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.539
SLC22A13	SLC34A1	ENSCJAP00000018717	ENSCJAP00000012722	Solute carrier family 22 member 13.	Solute carrier family 34 member 1.	0.541
SLC22A13	XYLB	ENSCJAP00000018717	ENSCJAP00000047601	Solute carrier family 22 member 13.	Xylulokinase.	0.557

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.841

expected number of edges:

16

PPI enrichment p-value:

7.42e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006783

Heme biosynthetic process

3 of 13

1.97

1.51

0.0010

GO:0045333

Cellular respiration

3 of 47

1.41

0.82

0.0155

GO:0006119

Oxidative phosphorylation

2 of 11

1.86

0.8

0.0292

GO:0022904

Respiratory electron transport chain

2 of 15

1.73

0.68

0.0473

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0015078

Proton transmembrane transporter activity

5 of 19

2.02

2.81

1.06e-06

GO:0022853

Active ion transmembrane transporter activity

5 of 37

1.73

2.2

6.94e-06

GO:0004129

Cytochrome-c oxidase activity

3 of 5

2.38

2.19

7.10e-05

GO:0009055

Electron transfer activity

5 of 41

1.69

2.12

8.35e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

3 of 9

2.13

1.78

0.00034

GO:0016021

Integral component of membrane

8 of 885

0.56

0.38

0.0166

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3096

Mixed, incl. Cytochrome-c oxidase activity, and RDD family

7 of 11

2.41

5.72

1.63e-12

CL:3098

Cytochrome-c oxidase activity, and Rieske iron-sulphur protein

4 of 6

2.43

3.22

6.34e-07

CL:2786

Mixed, incl. Tetrapyrrole biosynthetic process, and Oxidative phosphorylation

9 of 198

1.26

1.83

1.17e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

7 of 58

1.69

2.98

4.33e-09

map00860

Porphyrin and chlorophyll metabolism

4 of 61

1.42

1.24

0.00084

map01100

Metabolic pathways

10 of 1709

0.37

0.28

0.0236

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

3 of 14

1.94

1.33

0.0024

GOCC:0005739

Mitochondrion

3 of 50

1.38

0.66

0.0392

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

4 of 7

2.36

3.0

1.51e-06

KW-0679

Respiratory chain

3 of 3

2.6

2.47

2.55e-05

KW-0408

Iron

5 of 68

1.47

1.67

3.38e-05

KW-0350

Heme biosynthesis

2 of 2

2.6

1.54

0.0015

KW-0186

Copper

2 of 3

2.43

1.45

0.0021

(more ...)

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