STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYYPeptide YY. (97 aa)    
Predicted Functional Partners:
NPY2R
Neuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family.
   
 0.994
NPY1R
Neuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.967
NPY5R
Neuropeptide Y receptor Y5.
    
 0.965
PPY
Pancreatic polypeptide.
   
 
0.958
NPY
Neuropeptide Y.
  
  
0.948
GPR83
G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family.
    
 0.913
GHRL
Appetite-regulating hormone isoform 1 preproprotein.
   
  
 0.900
CCK
Gastrin domain-containing protein.
      
 0.832
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
      
 0.824
SST
Somatostatin preproprotein.
   
 
 0.784
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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