STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (417 aa)    
Predicted Functional Partners:
MST1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
  
0.705
HGF
Hepatocyte growth factor; Belongs to the peptidase S1 family.
  
0.703
MST1R
Macrophage stimulating 1 receptor.
    
 0.626
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 0.618
SPINT1
Serine peptidase inhibitor, Kunitz type 1.
   
 0.601
HGFAC
HGF activator.
  
0.502
ENSCJAP00000075646
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
   0.495
SPINT2
Kunitz-type protease inhibitor 2 isoform a.
    
 0.479
IGKV5-2
Immunoglobulin kappa variable 5-2.
    
  0.467
ENSCJAP00000056861
Ig-like domain-containing protein.
    
  0.467
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.