SST protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SST

Somatostatin preproprotein. (116 aa)

Predicted Functional Partners:

SSTR2

0.993

SSTR1

0.993

SSTR5

0.992

SSTR3

0.991

CORT

0.987

SSTR4

0.985

NPY

0.956

PVALB

0.954

CCK

0.942

GAL

0.936

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCK	GAL	ENSCJAP00000073128	ENSCJAP00000029196	Gastrin domain-containing protein.	GALANIN domain-containing protein.	0.819
CCK	NPY	ENSCJAP00000073128	ENSCJAP00000069867	Gastrin domain-containing protein.	Neuropeptide Y.	0.938
CCK	PVALB	ENSCJAP00000073128	ENSCJAP00000025689	Gastrin domain-containing protein.	Parvalbumin alpha; Belongs to the parvalbumin family.	0.904
CCK	SST	ENSCJAP00000073128	ENSCJAP00000026512	Gastrin domain-containing protein.	Somatostatin preproprotein.	0.942
CCK	SSTR1	ENSCJAP00000073128	ENSCJAP00000065748	Gastrin domain-containing protein.	Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.467
CCK	SSTR2	ENSCJAP00000073128	ENSCJAP00000037066	Gastrin domain-containing protein.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.404
CCK	SSTR4	ENSCJAP00000073128	ENSCJAP00000040948	Gastrin domain-containing protein.	Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.420
CCK	SSTR5	ENSCJAP00000073128	ENSCJAP00000004818	Gastrin domain-containing protein.	Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.473
CORT	GAL	ENSCJAP00000009283	ENSCJAP00000029196	Cortistatin preproprotein.	GALANIN domain-containing protein.	0.503
CORT	NPY	ENSCJAP00000009283	ENSCJAP00000069867	Cortistatin preproprotein.	Neuropeptide Y.	0.659
CORT	PVALB	ENSCJAP00000009283	ENSCJAP00000025689	Cortistatin preproprotein.	Parvalbumin alpha; Belongs to the parvalbumin family.	0.428
CORT	SST	ENSCJAP00000009283	ENSCJAP00000026512	Cortistatin preproprotein.	Somatostatin preproprotein.	0.987
CORT	SSTR1	ENSCJAP00000009283	ENSCJAP00000065748	Cortistatin preproprotein.	Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.954
CORT	SSTR2	ENSCJAP00000009283	ENSCJAP00000037066	Cortistatin preproprotein.	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.959
CORT	SSTR3	ENSCJAP00000009283	ENSCJAP00000051990	Cortistatin preproprotein.	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.951
CORT	SSTR4	ENSCJAP00000009283	ENSCJAP00000040948	Cortistatin preproprotein.	Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.957
CORT	SSTR5	ENSCJAP00000009283	ENSCJAP00000004818	Cortistatin preproprotein.	Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.947
GAL	CCK	ENSCJAP00000029196	ENSCJAP00000073128	GALANIN domain-containing protein.	Gastrin domain-containing protein.	0.819
GAL	CORT	ENSCJAP00000029196	ENSCJAP00000009283	GALANIN domain-containing protein.	Cortistatin preproprotein.	0.503
GAL	NPY	ENSCJAP00000029196	ENSCJAP00000069867	GALANIN domain-containing protein.	Neuropeptide Y.	0.894

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

47

PPI enrichment p-value:

0.0318

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 309

1.77

4.66

3.02e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 155

2.03

6.04

7.21e-17

GO:0019843

rRNA binding

4 of 43

2.19

2.52

1.03e-05

GO:0003723

RNA binding

6 of 1039

0.98

0.69

0.0076

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 177

1.97

5.71

1.28e-16

GO:0044391

Ribosomal subunit

7 of 130

1.95

3.98

2.21e-10

GO:0015935

Small ribosomal subunit

4 of 48

2.14

2.6

5.79e-06

GO:0022626

Cytosolic ribosome

4 of 52

2.11

2.56

6.27e-06

GO:0015934

Large ribosomal subunit

3 of 81

1.79

1.29

0.0023

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14887

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

10 of 101

2.22

7.32

1.83e-18

CL:14896

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

9 of 90

2.22

6.89

5.10e-17

CL:14897

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 78

2.18

5.13

3.18e-12

CL:14902

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

6 of 69

2.16

4.31

4.44e-10

CL:14907

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

4 of 45

2.17

2.72

3.52e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 176

1.98

5.91

1.90e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 108

2.09

5.17

5.36e-13

MAP-72737

Cap-dependent Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-72613

Eukaryotic Translation Initiation

8 of 124

2.03

4.94

7.74e-13

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

7 of 94

2.09

4.68

1.66e-11

MAP-72689

Formation of a pool of free 40S subunits

7 of 98

2.08

4.63

1.75e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022626

Cytosolic ribosome

6 of 51

2.29

4.51

4.67e-10

GOCC:0022627

Cytosolic small ribosomal subunit

5 of 25

2.52

4.4

2.82e-09

GOCC:1990904

Ribonucleoprotein complex

6 of 402

1.4

1.66

1.22e-05

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 1957

0.78

0.55

0.0066

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

5 of 59

2.15

3.44

6.54e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04758

Ribosomal protein S30

3 of 3

3.22

2.86

6.73e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006846

Ribosomal protein S30

2 of 2

3.22

1.05

0.0130

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