node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FZD10 | LRP5 | ENSCJAP00000068385 | ENSCJAP00000028989 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.941 |
FZD10 | LRP6 | ENSCJAP00000068385 | ENSCJAP00000054046 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.944 |
FZD10 | WIF1 | ENSCJAP00000068385 | ENSCJAP00000026960 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Wnt inhibitory factor 1. | 0.477 |
FZD10 | WNT7A | ENSCJAP00000068385 | ENSCJAP00000031115 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] | 0.905 |
FZD4 | LRP5 | ENSCJAP00000001124 | ENSCJAP00000028989 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.988 |
FZD4 | LRP6 | ENSCJAP00000001124 | ENSCJAP00000054046 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.986 |
FZD4 | WNT7A | ENSCJAP00000001124 | ENSCJAP00000031115 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] | 0.930 |
FZD5 | LRP5 | ENSCJAP00000041103 | ENSCJAP00000028989 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.970 |
FZD5 | LRP6 | ENSCJAP00000041103 | ENSCJAP00000054046 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.980 |
FZD5 | WNT7A | ENSCJAP00000041103 | ENSCJAP00000031115 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] | 0.927 |
FZD9 | LRP5 | ENSCJAP00000058483 | ENSCJAP00000028989 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.937 |
FZD9 | LRP6 | ENSCJAP00000058483 | ENSCJAP00000054046 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.940 |
FZD9 | WNT7A | ENSCJAP00000058483 | ENSCJAP00000031115 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] | 0.906 |
GPC3 | NOTUM | ENSCJAP00000007662 | ENSCJAP00000033755 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Notum, palmitoleoyl-protein carboxylesterase. | 0.714 |
GPC3 | WNT7A | ENSCJAP00000007662 | ENSCJAP00000031115 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] | 0.918 |
LRP5 | FZD10 | ENSCJAP00000028989 | ENSCJAP00000068385 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.941 |
LRP5 | FZD4 | ENSCJAP00000028989 | ENSCJAP00000001124 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.988 |
LRP5 | FZD5 | ENSCJAP00000028989 | ENSCJAP00000041103 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.970 |
LRP5 | FZD9 | ENSCJAP00000028989 | ENSCJAP00000058483 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.937 |
LRP5 | LRP6 | ENSCJAP00000028989 | ENSCJAP00000054046 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.988 |