HMGCR protein (Callithrix jacchus) - STRING interaction network

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Predicted Interactions

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Score

HMGCR

3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)

Predicted Functional Partners:

HMGCS1

0.999

HMGCS2

0.997

MVK

0.966

SQLE

0.964

INSIG1

0.940

INSIG2

0.935

PRKAA1

0.928

PRKAG2

0.922

PRKAG1

0.922

PRKAG3

0.922

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMGCR	HMGCS1	ENSCJAP00000031281	ENSCJAP00000002308	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
HMGCR	HMGCS2	ENSCJAP00000031281	ENSCJAP00000037020	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.997
HMGCR	INSIG1	ENSCJAP00000031281	ENSCJAP00000077298	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.940
HMGCR	INSIG2	ENSCJAP00000031281	ENSCJAP00000069901	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).	0.935
HMGCR	MVK	ENSCJAP00000031281	ENSCJAP00000069507	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase.	0.966
HMGCR	PRKAA1	ENSCJAP00000031281	ENSCJAP00000013705	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Non-specific serine/threonine protein kinase.	0.928
HMGCR	PRKAG1	ENSCJAP00000031281	ENSCJAP00000038771	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.922
HMGCR	PRKAG2	ENSCJAP00000031281	ENSCJAP00000037977	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.922
HMGCR	PRKAG3	ENSCJAP00000031281	ENSCJAP00000073045	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein kinase AMP-activated non-catalytic subunit gamma 3.	0.922
HMGCR	SQLE	ENSCJAP00000031281	ENSCJAP00000023410	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Squalene epoxidase.	0.964
HMGCS1	HMGCR	ENSCJAP00000002308	ENSCJAP00000031281	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
HMGCS1	HMGCS2	ENSCJAP00000002308	ENSCJAP00000037020	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.915
HMGCS1	INSIG1	ENSCJAP00000002308	ENSCJAP00000077298	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.710
HMGCS1	INSIG2	ENSCJAP00000002308	ENSCJAP00000069901	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).	0.408
HMGCS1	MVK	ENSCJAP00000002308	ENSCJAP00000069507	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase.	0.810
HMGCS1	SQLE	ENSCJAP00000002308	ENSCJAP00000023410	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Squalene epoxidase.	0.969
HMGCS2	HMGCR	ENSCJAP00000037020	ENSCJAP00000031281	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.997
HMGCS2	HMGCS1	ENSCJAP00000037020	ENSCJAP00000002308	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.915
HMGCS2	INSIG1	ENSCJAP00000037020	ENSCJAP00000077298	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.434
HMGCS2	MVK	ENSCJAP00000037020	ENSCJAP00000069507	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Mevalonate kinase.	0.808