WIPI2 protein (Callithrix jacchus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Edges:

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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Experiments

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[Homology]

Score

WIPI2

WD repeat domain, phosphoinositide interacting 2. (402 aa)

Predicted Functional Partners:

ATG16L1

0.990

ATG12

0.979

ATG5

0.977

ATG16L2

0.904

ULK2

0.884

PIK3R4

0.876

PIK3C3

0.875

ATG3

0.865

BECN1

0.851

ATG14

0.846

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG14	ENSCJAP00000059203	ENSCJAP00000034010	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Beclin 1-associated autophagy-related key regulator.	0.959
ATG12	ATG16L1	ENSCJAP00000059203	ENSCJAP00000077866	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 16 like 1.	0.999
ATG12	ATG16L2	ENSCJAP00000059203	ENSCJAP00000027660	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 16 like 2.	0.995
ATG12	ATG3	ENSCJAP00000059203	ENSCJAP00000037864	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 3.	0.999
ATG12	ATG5	ENSCJAP00000059203	ENSCJAP00000011649	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	BECN1	ENSCJAP00000059203	ENSCJAP00000024165	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Beclin-1.	0.964
ATG12	PIK3C3	ENSCJAP00000059203	ENSCJAP00000058081	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.943
ATG12	PIK3R4	ENSCJAP00000059203	ENSCJAP00000006032	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphoinositide-3-kinase regulatory subunit 4.	0.930
ATG12	ULK2	ENSCJAP00000059203	ENSCJAP00000021791	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Unc-51 like autophagy activating kinase 2.	0.948
ATG12	WIPI2	ENSCJAP00000059203	ENSCJAP00000033596	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain, phosphoinositide interacting 2.	0.979
ATG14	ATG12	ENSCJAP00000034010	ENSCJAP00000059203	Beclin 1-associated autophagy-related key regulator.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.959
ATG14	ATG16L1	ENSCJAP00000034010	ENSCJAP00000077866	Beclin 1-associated autophagy-related key regulator.	Autophagy related 16 like 1.	0.912
ATG14	ATG16L2	ENSCJAP00000034010	ENSCJAP00000027660	Beclin 1-associated autophagy-related key regulator.	Autophagy related 16 like 2.	0.841
ATG14	ATG3	ENSCJAP00000034010	ENSCJAP00000037864	Beclin 1-associated autophagy-related key regulator.	Autophagy-related protein 3.	0.798
ATG14	ATG5	ENSCJAP00000034010	ENSCJAP00000011649	Beclin 1-associated autophagy-related key regulator.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.947
ATG14	BECN1	ENSCJAP00000034010	ENSCJAP00000024165	Beclin 1-associated autophagy-related key regulator.	Beclin-1.	0.999
ATG14	PIK3C3	ENSCJAP00000034010	ENSCJAP00000058081	Beclin 1-associated autophagy-related key regulator.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.999
ATG14	PIK3R4	ENSCJAP00000034010	ENSCJAP00000006032	Beclin 1-associated autophagy-related key regulator.	Phosphoinositide-3-kinase regulatory subunit 4.	0.999
ATG14	ULK2	ENSCJAP00000034010	ENSCJAP00000021791	Beclin 1-associated autophagy-related key regulator.	Unc-51 like autophagy activating kinase 2.	0.995
ATG14	WIPI2	ENSCJAP00000034010	ENSCJAP00000033596	Beclin 1-associated autophagy-related key regulator.	WD repeat domain, phosphoinositide interacting 2.	0.846

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016180

snRNA processing

4 of 26

2.43

2.6

1.15e-05

GO:0034472

snRNA 3-end processing

3 of 20

2.42

1.79

0.00045

GO:0034720

Histone H3-K4 demethylation

2 of 9

2.59

1.0

0.0152

GO:0042135

Neurotransmitter catabolic process

2 of 12

2.47

0.91

0.0223

GO:0006584

Catecholamine metabolic process

2 of 18

2.29

0.81

0.0322

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140682

Histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity

2 of 2

3.25

1.4

0.0030

GO:0097621

Monoamine oxidase activity

2 of 3

3.07

1.4

0.0030

GO:0052596

Phenethylamine:oxygen oxidoreductase (deaminating) activity

2 of 2

3.25

1.4

0.0030

GO:0052595

Aliphatic-amine oxidase activity

2 of 2

3.25

1.4

0.0030

GO:0008131

Primary amine oxidase activity

2 of 3

3.07

1.4

0.0030

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032039

Integrator complex

4 of 17

2.62

3.39

4.09e-07

GO:0005694

Chromosome

5 of 797

1.04

0.6

0.0274

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28450736

(2017) Histone lysine demethylases in mammalian embryonic development.

2 of 13

2.43

0.73

0.0463

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21251

Integrator complex

4 of 6

3.07

4.0

4.84e-08

CL:9408

Structural constituent of chromatin, and Associated with SET domains

3 of 33

2.21

1.81

0.00033

CL:9464

Histone H2B, and 6-phosphogluconate dehydrogenase, NADP-binding

2 of 5

2.85

1.54

0.0016

CL:9397

Chromatin organization, and Epigenetic regulation of gene expression

4 of 200

1.55

1.31

0.0010

CL:1141

Mixed, incl. Histidine metabolism, and Aldo-keto reductase family 1 member A1

2 of 17

2.32

1.09

0.0098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cmk00360

Phenylalanine metabolism

2 of 10

2.55

1.36

0.0032

cmk00340

Histidine metabolism

2 of 14

2.4

1.35

0.0032

cmk00982

Drug metabolism - cytochrome P450

2 of 17

2.32

1.34

0.0032

cmk00350

Tyrosine metabolism

2 of 20

2.25

1.33

0.0032

cmk00380

Tryptophan metabolism

2 of 33

2.03

1.17

0.0057

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-141333

Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

2 of 2

3.25

1.58

0.0014

MAP-6807505

RNA polymerase II transcribes snRNA genes

4 of 112

1.8

1.53

0.00062

MAP-140179

Amine Oxidase reactions

2 of 6

2.77

1.3

0.0043

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032039

Integrator complex

4 of 17

2.62

3.35

4.90e-07

GOCC:0000785

Chromatin

4 of 210

1.53

1.12

0.0033

GOCC:0000786

Nucleosome

2 of 18

2.29

0.92

0.0203

GOCC:0043229

Intracellular organelle

11 of 7678

0.4

0.3

0.0183

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

3 of 55

1.98

1.47

0.0013

KW-0560

Oxidoreductase

3 of 178

1.47

0.87

0.0133

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04433

SWIRM domain

2 of 5

2.85

1.04

0.0130

PF01266

FAD dependent oxidoreductase

2 of 9

2.59

0.97

0.0170

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002937

Amine oxidase

4 of 12

2.77

3.34

6.52e-07

IPR036188

FAD/NAD(P)-binding domain superfamily

4 of 60

2.07

1.99

0.00011

IPR001613

Flavin amine oxidase

2 of 2

3.25

1.34

0.0038

IPR022712

Beta-Casp domain

2 of 4

2.95

1.19

0.0071

IPR007526

SWIRM domain

2 of 6

2.77

1.09

0.0105

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01027

Beta-Casp domain

2 of 4

2.95

1.38

0.0032

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