STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (778 aa)    
Predicted Functional Partners:
FKBP5
Peptidylprolyl isomerase.
   
 0.971
NCOA2
Nuclear receptor coactivator.
   
 0.946
NCOR1
Nuclear receptor corepressor 1.
    
 0.936
NCOA1
Nuclear receptor coactivator.
   
 0.927
HSP90AA1
HATPase_c domain-containing protein.
   
 0.924
ENSCJAP00000074070
Uncharacterized protein.
   
 0.924
FKBP4
Peptidylprolyl isomerase.
   
 0.919
PTGES3
Prostaglandin E synthase 3.
   
 0.914
ENSCJAP00000073695
Uncharacterized protein.
   
 0.914
STIP1
Stress induced phosphoprotein 1.
   
 0.912
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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