STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa)    
Predicted Functional Partners:
MYPN
Myopalladin isoform a.
      
 0.812
FAM13A
Rho-GAP domain-containing protein.
      
 0.744
ISG15
ISG15 ubiquitin like modifier.
   
 0.700
TRIP12
Uncharacterized protein.
   
 
0.687
PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]
      
 0.609
UBE2L3
Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.555
MX2
MX dynamin like GTPase 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
   
 
 0.532
PSMD4
26S proteasome non-ATPase regulatory subunit 4.
    
 
 0.514
SPX
Spexin hormone.
      
 0.502
TRIM22
Tripartite motif containing 22.
   
 0.499
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.