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HMGB1 protein (Callithrix jacchus) - STRING interaction network
"HMGB1" - High mobility group protein B1 in Callithrix jacchus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)    
Predicted Functional Partners:
BECN1
Beclin 1, autophagy related (363 aa)
     
  0.886
BECN2
Beclin 2 (439 aa)
       
  0.819
ENSCJAG00000008384
Uncharacterized protein (216 aa)
       
   
0.800
ENSCJAG00000008378
Uncharacterized protein (187 aa)
       
   
0.800
TLR4
Toll-like receptor 4 (811 aa)
       
 
  0.786
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family (395 aa)
     
 
  0.758
TLR2
Toll-like receptor 2 (784 aa)
       
 
  0.690
HMGB2
High mobility group box 2 (205 aa)
     
 
0.690
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit; Suppressor of Ty 16 homolog (S. cerevisiae) (1047 aa)
     
 
  0.651
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (1654 aa)
     
 
  0.577
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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