node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD19 | GRB2 | ENSCJAP00000070708 | ENSCJAP00000067776 | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | Growth factor receptor-bound protein 2 isoform 1. | 0.697 |
CD19 | PLCG2 | ENSCJAP00000070708 | ENSCJAP00000071450 | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.587 |
CD19 | SYK | ENSCJAP00000070708 | ENSCJAP00000010427 | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | Uncharacterized protein. | 0.948 |
CD19 | VAV1 | ENSCJAP00000070708 | ENSCJAP00000043076 | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | Vav guanine nucleotide exchange factor 1. | 0.990 |
CD19 | ZAP70 | ENSCJAP00000070708 | ENSCJAP00000021145 | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | Zeta chain of T cell receptor associated protein kinase 70. | 0.453 |
GRB2 | CD19 | ENSCJAP00000067776 | ENSCJAP00000070708 | Growth factor receptor-bound protein 2 isoform 1. | B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] | 0.697 |
GRB2 | ITK | ENSCJAP00000067776 | ENSCJAP00000035020 | Growth factor receptor-bound protein 2 isoform 1. | Tyrosine-protein kinase. | 0.783 |
GRB2 | LCP2 | ENSCJAP00000067776 | ENSCJAP00000021432 | Growth factor receptor-bound protein 2 isoform 1. | Lymphocyte cytosolic protein 2. | 0.997 |
GRB2 | PLCG1 | ENSCJAP00000067776 | ENSCJAP00000033427 | Growth factor receptor-bound protein 2 isoform 1. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.964 |
GRB2 | PLCG2 | ENSCJAP00000067776 | ENSCJAP00000071450 | Growth factor receptor-bound protein 2 isoform 1. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.906 |
GRB2 | PTPN11 | ENSCJAP00000067776 | ENSCJAP00000022937 | Growth factor receptor-bound protein 2 isoform 1. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.999 |
GRB2 | RAC3 | ENSCJAP00000067776 | ENSCJAP00000033666 | Growth factor receptor-bound protein 2 isoform 1. | Ras-related C3 botulinum toxin substrate 3. | 0.517 |
GRB2 | SYK | ENSCJAP00000067776 | ENSCJAP00000010427 | Growth factor receptor-bound protein 2 isoform 1. | Uncharacterized protein. | 0.824 |
GRB2 | VAV1 | ENSCJAP00000067776 | ENSCJAP00000043076 | Growth factor receptor-bound protein 2 isoform 1. | Vav guanine nucleotide exchange factor 1. | 0.979 |
GRB2 | ZAP70 | ENSCJAP00000067776 | ENSCJAP00000021145 | Growth factor receptor-bound protein 2 isoform 1. | Zeta chain of T cell receptor associated protein kinase 70. | 0.843 |
ITK | GRB2 | ENSCJAP00000035020 | ENSCJAP00000067776 | Tyrosine-protein kinase. | Growth factor receptor-bound protein 2 isoform 1. | 0.783 |
ITK | LCP2 | ENSCJAP00000035020 | ENSCJAP00000021432 | Tyrosine-protein kinase. | Lymphocyte cytosolic protein 2. | 0.993 |
ITK | PLCG1 | ENSCJAP00000035020 | ENSCJAP00000033427 | Tyrosine-protein kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.980 |
ITK | PLCG2 | ENSCJAP00000035020 | ENSCJAP00000071450 | Tyrosine-protein kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.563 |
ITK | PTPN11 | ENSCJAP00000035020 | ENSCJAP00000022937 | Tyrosine-protein kinase. | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. | 0.517 |