STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD4Ig-like domain-containing protein. (457 aa)    
Predicted Functional Partners:
CCR5
C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family.
   
 0.995
LCK
Tyrosine-protein kinase.
   
 0.990
ZAP70
Zeta chain of T cell receptor associated protein kinase 70.
   
 0.989
CAJA-DRA
HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.
   
 0.988
CXCR4
C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]
    
 0.985
HLA-DQA2
Major histocompatibility complex, class II, DQ alpha 2; Belongs to the MHC class II family.
   
 0.980
CD8A
CD8a molecule.
   
 0.980
Caja-DQB1
Ig-like domain-containing protein.
   
 0.979
Caja-DQA1
Ig-like domain-containing protein; Belongs to the MHC class II family.
   
 0.975
IL16
Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
   
 0.972
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.