node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREBBP | MED1 | ENSCJAP00000036680 | ENSCJAP00000015874 | CREB-binding protein isoform a. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.775 |
CREBBP | NCOA1 | ENSCJAP00000036680 | ENSCJAP00000014783 | CREB-binding protein isoform a. | Nuclear receptor coactivator. | 0.995 |
CREBBP | NCOR1 | ENSCJAP00000036680 | ENSCJAP00000022329 | CREB-binding protein isoform a. | Nuclear receptor corepressor 1. | 0.786 |
CREBBP | NCOR2 | ENSCJAP00000036680 | ENSCJAP00000049515 | CREB-binding protein isoform a. | Nuclear receptor corepressor 2. | 0.739 |
CREBBP | PPARG | ENSCJAP00000036680 | ENSCJAP00000048822 | CREB-binding protein isoform a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.970 |
CREBBP | PPARGC1A | ENSCJAP00000036680 | ENSCJAP00000050855 | CREB-binding protein isoform a. | PPARG coactivator 1 alpha. | 0.752 |
CREBBP | RXRA | ENSCJAP00000036680 | ENSCJAP00000053089 | CREB-binding protein isoform a. | Retinoid X receptor alpha. | 0.946 |
CREBBP | RXRB | ENSCJAP00000036680 | ENSCJAP00000040245 | CREB-binding protein isoform a. | Retinoid X receptor beta. | 0.881 |
CREBBP | RXRG | ENSCJAP00000036680 | ENSCJAP00000008496 | CREB-binding protein isoform a. | Retinoic acid receptor RXR-gamma isoform a. | 0.896 |
CREBBP | SIRT1 | ENSCJAP00000036680 | ENSCJAP00000046567 | CREB-binding protein isoform a. | Sirtuin 1. | 0.792 |
MED1 | CREBBP | ENSCJAP00000015874 | ENSCJAP00000036680 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | CREB-binding protein isoform a. | 0.775 |
MED1 | NCOA1 | ENSCJAP00000015874 | ENSCJAP00000014783 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.793 |
MED1 | NCOR1 | ENSCJAP00000015874 | ENSCJAP00000022329 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 1. | 0.606 |
MED1 | NCOR2 | ENSCJAP00000015874 | ENSCJAP00000049515 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor corepressor 2. | 0.663 |
MED1 | PPARG | ENSCJAP00000015874 | ENSCJAP00000048822 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.977 |
MED1 | PPARGC1A | ENSCJAP00000015874 | ENSCJAP00000050855 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | PPARG coactivator 1 alpha. | 0.419 |
MED1 | RXRA | ENSCJAP00000015874 | ENSCJAP00000053089 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.971 |
MED1 | RXRB | ENSCJAP00000015874 | ENSCJAP00000040245 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor beta. | 0.924 |
MED1 | RXRG | ENSCJAP00000015874 | ENSCJAP00000008496 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-gamma isoform a. | 0.935 |
NCOA1 | CREBBP | ENSCJAP00000014783 | ENSCJAP00000036680 | Nuclear receptor coactivator. | CREB-binding protein isoform a. | 0.995 |