STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKACGUncharacterized protein; Belongs to the protein kinase superfamily. (360 aa)    
Predicted Functional Partners:
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.997
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.996
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.982
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.978
RYR2
Ryanodine receptor 2.
    
 0.970
PKIA
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
   
 0.966
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.965
PLIN1
Perilipin; Belongs to the perilipin family.
   
 0.958
RHOA
Transforming protein RhoA.
    
 0.950
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
     
 0.950
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.