| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREB1 | PRKACA | ENSCJAP00000043931 | ENSCJAP00000061444 | Cyclic AMP-responsive element-binding protein 1 isoform B. | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.968 |
| CREB1 | PRKACB | ENSCJAP00000043931 | ENSCJAP00000046709 | Cyclic AMP-responsive element-binding protein 1 isoform B. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.985 |
| PKIA | PRKACA | ENSCJAP00000070617 | ENSCJAP00000061444 | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.965 |
| PKIA | PRKACB | ENSCJAP00000070617 | ENSCJAP00000046709 | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.971 |
| PLN | PRKACA | ENSCJAP00000070174 | ENSCJAP00000061444 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.969 |
| PLN | PRKACB | ENSCJAP00000070174 | ENSCJAP00000046709 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.971 |
| PPP1R1B | PRKACA | ENSCJAP00000009548 | ENSCJAP00000061444 | Protein phosphatase 1 regulatory inhibitor subunit 1B. | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | 0.966 |
| PPP1R1B | PRKACB | ENSCJAP00000009548 | ENSCJAP00000046709 | Protein phosphatase 1 regulatory inhibitor subunit 1B. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.976 |
| PRKACA | CREB1 | ENSCJAP00000061444 | ENSCJAP00000043931 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Cyclic AMP-responsive element-binding protein 1 isoform B. | 0.968 |
| PRKACA | PKIA | ENSCJAP00000061444 | ENSCJAP00000070617 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. | 0.965 |
| PRKACA | PLN | ENSCJAP00000061444 | ENSCJAP00000070174 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | 0.969 |
| PRKACA | PPP1R1B | ENSCJAP00000061444 | ENSCJAP00000009548 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Protein phosphatase 1 regulatory inhibitor subunit 1B. | 0.966 |
| PRKACA | PRKACB | ENSCJAP00000061444 | ENSCJAP00000046709 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | 0.973 |
| PRKACA | PRKAR1A | ENSCJAP00000061444 | ENSCJAP00000044300 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Protein kinase cAMP-dependent type I regulatory subunit alpha. | 0.997 |
| PRKACA | PRKAR1B | ENSCJAP00000061444 | ENSCJAP00000045253 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Protein kinase cAMP-dependent type I regulatory subunit beta. | 0.996 |
| PRKACA | PRKAR2A | ENSCJAP00000061444 | ENSCJAP00000005968 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Protein kinase cAMP-dependent type II regulatory subunit alpha. | 0.981 |
| PRKACA | PRKAR2B | ENSCJAP00000061444 | ENSCJAP00000049624 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Protein kinase cAMP-dependent type II regulatory subunit beta. | 0.983 |
| PRKACA | SMO | ENSCJAP00000061444 | ENSCJAP00000018990 | cAMP-dependent protein kinase catalytic subunit alpha isoform 1; Belongs to the protein kinase superfamily. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.968 |
| PRKACB | CREB1 | ENSCJAP00000046709 | ENSCJAP00000043931 | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | Cyclic AMP-responsive element-binding protein 1 isoform B. | 0.985 |
| PRKACB | PKIA | ENSCJAP00000046709 | ENSCJAP00000070617 | cAMP-dependent protein kinase catalytic subunit beta isoform 1; Belongs to the protein kinase superfamily. | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. | 0.971 |
