ICOS protein (Callithrix jacchus) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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Score

ICOS

Inducible T cell costimulator. (211 aa)

Predicted Functional Partners:

ICOSLG

0.997

CD40LG

0.996

PIK3R1

0.964

CTLA4

0.963

PIK3CA

0.955

PIK3R2

0.952

PIK3R3

0.952

PIK3CB

0.935

CXCR5

0.891

CD4

0.871

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD40LG	ENSCJAP00000043597	ENSCJAP00000056697	Ig-like domain-containing protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.955
CD4	CTLA4	ENSCJAP00000043597	ENSCJAP00000064098	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.923
CD4	CXCR5	ENSCJAP00000043597	ENSCJAP00000025039	Ig-like domain-containing protein.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.872
CD4	ICOS	ENSCJAP00000043597	ENSCJAP00000069147	Ig-like domain-containing protein.	Inducible T cell costimulator.	0.871
CD40LG	CD4	ENSCJAP00000056697	ENSCJAP00000043597	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Ig-like domain-containing protein.	0.955
CD40LG	CTLA4	ENSCJAP00000056697	ENSCJAP00000064098	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Cytotoxic T-lymphocyte associated protein 4.	0.852
CD40LG	CXCR5	ENSCJAP00000056697	ENSCJAP00000025039	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.759
CD40LG	ICOS	ENSCJAP00000056697	ENSCJAP00000069147	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Inducible T cell costimulator.	0.996
CD40LG	ICOSLG	ENSCJAP00000056697	ENSCJAP00000006492	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	Uncharacterized protein.	0.651
CTLA4	CD4	ENSCJAP00000064098	ENSCJAP00000043597	Cytotoxic T-lymphocyte associated protein 4.	Ig-like domain-containing protein.	0.923
CTLA4	CD40LG	ENSCJAP00000064098	ENSCJAP00000056697	Cytotoxic T-lymphocyte associated protein 4.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.852
CTLA4	CXCR5	ENSCJAP00000064098	ENSCJAP00000025039	Cytotoxic T-lymphocyte associated protein 4.	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.614
CTLA4	ICOS	ENSCJAP00000064098	ENSCJAP00000069147	Cytotoxic T-lymphocyte associated protein 4.	Inducible T cell costimulator.	0.963
CTLA4	ICOSLG	ENSCJAP00000064098	ENSCJAP00000006492	Cytotoxic T-lymphocyte associated protein 4.	Uncharacterized protein.	0.953
CTLA4	PIK3R1	ENSCJAP00000064098	ENSCJAP00000029505	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1.	0.544
CTLA4	PIK3R2	ENSCJAP00000064098	ENSCJAP00000025887	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.489
CTLA4	PIK3R3	ENSCJAP00000064098	ENSCJAP00000039097	Cytotoxic T-lymphocyte associated protein 4.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.489
CXCR5	CD4	ENSCJAP00000025039	ENSCJAP00000043597	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.872
CXCR5	CD40LG	ENSCJAP00000025039	ENSCJAP00000056697	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.759
CXCR5	CTLA4	ENSCJAP00000025039	ENSCJAP00000064098	C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family.	Cytotoxic T-lymphocyte associated protein 4.	0.614