IL10RB protein (Callithrix jacchus) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

IL10RB

Uncharacterized protein. (547 aa)

Predicted Functional Partners:

IL10RA

0.990

TYK2

0.985

IL10

0.984

JAK1

0.980

IL22

0.980

IL22RA1

0.978

IL28B

0.966

IFNLR1

0.960

IL26

0.951

IFNL1

0.935

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNL1	IFNLR1	ENSCJAP00000025868	ENSCJAP00000038837	Interferon lambda 1.	Interferon lambda receptor 1.	0.944
IFNL1	IL10RA	ENSCJAP00000025868	ENSCJAP00000024017	Interferon lambda 1.	Interleukin 10 receptor subunit alpha.	0.729
IFNL1	IL10RB	ENSCJAP00000025868	ENSCJAP00000072470	Interferon lambda 1.	Uncharacterized protein.	0.935
IFNL1	IL22RA1	ENSCJAP00000025868	ENSCJAP00000038842	Interferon lambda 1.	Interleukin 22 receptor subunit alpha 1.	0.709
IFNLR1	IFNL1	ENSCJAP00000038837	ENSCJAP00000025868	Interferon lambda receptor 1.	Interferon lambda 1.	0.944
IFNLR1	IL10	ENSCJAP00000038837	ENSCJAP00000034416	Interferon lambda receptor 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.755
IFNLR1	IL10RB	ENSCJAP00000038837	ENSCJAP00000072470	Interferon lambda receptor 1.	Uncharacterized protein.	0.960
IFNLR1	IL22	ENSCJAP00000038837	ENSCJAP00000074107	Interferon lambda receptor 1.	Uncharacterized protein.	0.759
IFNLR1	IL22RA1	ENSCJAP00000038837	ENSCJAP00000038842	Interferon lambda receptor 1.	Interleukin 22 receptor subunit alpha 1.	0.671
IFNLR1	IL28B	ENSCJAP00000038837	ENSCJAP00000076673	Interferon lambda receptor 1.	Uncharacterized protein.	0.944
IFNLR1	JAK1	ENSCJAP00000038837	ENSCJAP00000030953	Interferon lambda receptor 1.	Tyrosine-protein kinase.	0.986
IFNLR1	TYK2	ENSCJAP00000038837	ENSCJAP00000012623	Interferon lambda receptor 1.	Tyrosine-protein kinase.	0.955
IL10	IFNLR1	ENSCJAP00000034416	ENSCJAP00000038837	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interferon lambda receptor 1.	0.755
IL10	IL10RA	ENSCJAP00000034416	ENSCJAP00000024017	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.996
IL10	IL10RB	ENSCJAP00000034416	ENSCJAP00000072470	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Uncharacterized protein.	0.984
IL10	IL22	ENSCJAP00000034416	ENSCJAP00000074107	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Uncharacterized protein.	0.890
IL10	IL22RA1	ENSCJAP00000034416	ENSCJAP00000038842	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22 receptor subunit alpha 1.	0.795
IL10	JAK1	ENSCJAP00000034416	ENSCJAP00000030953	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.868
IL10	TYK2	ENSCJAP00000034416	ENSCJAP00000012623	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.755
IL10RA	IFNL1	ENSCJAP00000024017	ENSCJAP00000025868	Interleukin 10 receptor subunit alpha.	Interferon lambda 1.	0.729