MYL5 protein (Callithrix jacchus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

MYL5

EF-hand domain-containing protein. (173 aa)

Predicted Functional Partners:

MYH9

0.954

MYH10

0.954

MYLK

0.928

LOC100409006

0.927

MYLK2

0.923

ROCK1

0.920

ROCK2

0.920

PPP1CA

0.732

LOC100410496

0.732

PPP1CC

0.732

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100409006	MYH10	ENSCJAP00000005237	ENSCJAP00000026354	Uncharacterized protein.	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.934
LOC100409006	MYH9	ENSCJAP00000005237	ENSCJAP00000025394	Uncharacterized protein.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.934
LOC100409006	MYL5	ENSCJAP00000005237	ENSCJAP00000072761	Uncharacterized protein.	EF-hand domain-containing protein.	0.927
LOC100410496	MYL5	ENSCJAP00000029920	ENSCJAP00000072761	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	EF-hand domain-containing protein.	0.732
LOC100410496	PPP1CA	ENSCJAP00000029920	ENSCJAP00000001692	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.964
LOC100410496	PPP1CC	ENSCJAP00000029920	ENSCJAP00000052805	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.900
LOC100410496	ROCK1	ENSCJAP00000029920	ENSCJAP00000038068	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.921
LOC100410496	ROCK2	ENSCJAP00000029920	ENSCJAP00000038079	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.921
MYH10	LOC100409006	ENSCJAP00000026354	ENSCJAP00000005237	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.934
MYH10	MYH9	ENSCJAP00000026354	ENSCJAP00000025394	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.966
MYH10	MYL5	ENSCJAP00000026354	ENSCJAP00000072761	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	EF-hand domain-containing protein.	0.954
MYH10	MYLK	ENSCJAP00000026354	ENSCJAP00000014081	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myosin light chain kinase.	0.539
MYH9	LOC100409006	ENSCJAP00000025394	ENSCJAP00000005237	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Uncharacterized protein.	0.934
MYH9	MYH10	ENSCJAP00000025394	ENSCJAP00000026354	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.966
MYH9	MYL5	ENSCJAP00000025394	ENSCJAP00000072761	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	EF-hand domain-containing protein.	0.954
MYH9	MYLK	ENSCJAP00000025394	ENSCJAP00000014081	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Myosin light chain kinase.	0.455
MYH9	ROCK2	ENSCJAP00000025394	ENSCJAP00000038079	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.445
MYL5	LOC100409006	ENSCJAP00000072761	ENSCJAP00000005237	EF-hand domain-containing protein.	Uncharacterized protein.	0.927
MYL5	LOC100410496	ENSCJAP00000072761	ENSCJAP00000029920	EF-hand domain-containing protein.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.732
MYL5	MYH10	ENSCJAP00000072761	ENSCJAP00000026354	EF-hand domain-containing protein.	Myosin-10 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.954

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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