GLRB protein (Callithrix jacchus) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

GLRB

Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (555 aa)

Predicted Functional Partners:

GPHN

0.943

GLRA1

0.751

GLRA3

0.740

ARHGEF9

0.729

GLRA4

0.704

GLRA2

0.700

NPY5R

0.627

KLHL32

0.577

GPR19

0.571

SLC6A5

0.571

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF9	GLRA1	ENSCJAP00000054637	ENSCJAP00000028368	Cdc42 guanine nucleotide exchange factor 9.	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.630
ARHGEF9	GLRA2	ENSCJAP00000054637	ENSCJAP00000007403	Cdc42 guanine nucleotide exchange factor 9.	Glycine receptor subunit alpha-2 isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.575
ARHGEF9	GLRA3	ENSCJAP00000054637	ENSCJAP00000009611	Cdc42 guanine nucleotide exchange factor 9.	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.621
ARHGEF9	GLRB	ENSCJAP00000054637	ENSCJAP00000074991	Cdc42 guanine nucleotide exchange factor 9.	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.729
ARHGEF9	GPHN	ENSCJAP00000054637	ENSCJAP00000042308	Cdc42 guanine nucleotide exchange factor 9.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.676
ARHGEF9	SLC6A5	ENSCJAP00000054637	ENSCJAP00000078361	Cdc42 guanine nucleotide exchange factor 9.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.505
GLRA1	ARHGEF9	ENSCJAP00000028368	ENSCJAP00000054637	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Cdc42 guanine nucleotide exchange factor 9.	0.630
GLRA1	GLRA4	ENSCJAP00000028368	ENSCJAP00000007391	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.605
GLRA1	GLRB	ENSCJAP00000028368	ENSCJAP00000074991	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.751
GLRA1	GPHN	ENSCJAP00000028368	ENSCJAP00000042308	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.802
GLRA1	SLC6A5	ENSCJAP00000028368	ENSCJAP00000078361	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.674
GLRA2	ARHGEF9	ENSCJAP00000007403	ENSCJAP00000054637	Glycine receptor subunit alpha-2 isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Cdc42 guanine nucleotide exchange factor 9.	0.575
GLRA2	GLRB	ENSCJAP00000007403	ENSCJAP00000074991	Glycine receptor subunit alpha-2 isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.700
GLRA2	GPHN	ENSCJAP00000007403	ENSCJAP00000042308	Glycine receptor subunit alpha-2 isoform A; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.595
GLRA3	ARHGEF9	ENSCJAP00000009611	ENSCJAP00000054637	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Cdc42 guanine nucleotide exchange factor 9.	0.621
GLRA3	GLRA4	ENSCJAP00000009611	ENSCJAP00000007391	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.457
GLRA3	GLRB	ENSCJAP00000009611	ENSCJAP00000074991	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.740
GLRA3	GPHN	ENSCJAP00000009611	ENSCJAP00000042308	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.643
GLRA4	GLRA1	ENSCJAP00000007391	ENSCJAP00000028368	Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.605
GLRA4	GLRA3	ENSCJAP00000007391	ENSCJAP00000009611	Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.457

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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