CCDC3 protein (Callithrix jacchus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CCDC3

Coiled-coil domain-containing protein 3. (270 aa)

Predicted Functional Partners:

MCUB

0.894

ADCY4

0.611

NEK6

0.581

COL15A1

0.569

SERPINF1

0.564

GRM7

0.505

PLAGL1

0.504

CDC42BPA

0.499

PLIN1

0.470

RBPJ

0.461

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	CCDC3	ENSCJAP00000012204	ENSCJAP00000076287	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Coiled-coil domain-containing protein 3.	0.611
ADCY4	COL15A1	ENSCJAP00000012204	ENSCJAP00000075221	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Collagen type XV alpha 1 chain.	0.441
ADCY4	SERPINF1	ENSCJAP00000012204	ENSCJAP00000003386	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Serpin family F member 1; Belongs to the serpin family.	0.424
CCDC3	ADCY4	ENSCJAP00000076287	ENSCJAP00000012204	Coiled-coil domain-containing protein 3.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.611
CCDC3	CDC42BPA	ENSCJAP00000076287	ENSCJAP00000073829	Coiled-coil domain-containing protein 3.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.499
CCDC3	COL15A1	ENSCJAP00000076287	ENSCJAP00000075221	Coiled-coil domain-containing protein 3.	Collagen type XV alpha 1 chain.	0.569
CCDC3	GRM7	ENSCJAP00000076287	ENSCJAP00000063883	Coiled-coil domain-containing protein 3.	Metabotropic glutamate receptor 7 isoform b.	0.505
CCDC3	MCUB	ENSCJAP00000076287	ENSCJAP00000029743	Coiled-coil domain-containing protein 3.	Mitochondrial calcium uniporter dominant negative beta subunit.	0.894
CCDC3	NEK6	ENSCJAP00000076287	ENSCJAP00000051011	Coiled-coil domain-containing protein 3.	NIMA related kinase 6; Belongs to the protein kinase superfamily.	0.581
CCDC3	PLAGL1	ENSCJAP00000076287	ENSCJAP00000077179	Coiled-coil domain-containing protein 3.	Zinc finger protein PLAGL1 isoform 2.	0.504
CCDC3	PLIN1	ENSCJAP00000076287	ENSCJAP00000023289	Coiled-coil domain-containing protein 3.	Perilipin; Belongs to the perilipin family.	0.470
CCDC3	RBPJ	ENSCJAP00000076287	ENSCJAP00000060076	Coiled-coil domain-containing protein 3.	Recombination signal binding protein for immunoglobulin kappa J region.	0.461
CCDC3	SERPINF1	ENSCJAP00000076287	ENSCJAP00000003386	Coiled-coil domain-containing protein 3.	Serpin family F member 1; Belongs to the serpin family.	0.564
CDC42BPA	CCDC3	ENSCJAP00000073829	ENSCJAP00000076287	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Coiled-coil domain-containing protein 3.	0.499
CDC42BPA	GRM7	ENSCJAP00000073829	ENSCJAP00000063883	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Metabotropic glutamate receptor 7 isoform b.	0.471
COL15A1	ADCY4	ENSCJAP00000075221	ENSCJAP00000012204	Collagen type XV alpha 1 chain.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.441
COL15A1	CCDC3	ENSCJAP00000075221	ENSCJAP00000076287	Collagen type XV alpha 1 chain.	Coiled-coil domain-containing protein 3.	0.569
COL15A1	SERPINF1	ENSCJAP00000075221	ENSCJAP00000003386	Collagen type XV alpha 1 chain.	Serpin family F member 1; Belongs to the serpin family.	0.502
GRM7	CCDC3	ENSCJAP00000063883	ENSCJAP00000076287	Metabotropic glutamate receptor 7 isoform b.	Coiled-coil domain-containing protein 3.	0.505
GRM7	CDC42BPA	ENSCJAP00000063883	ENSCJAP00000073829	Metabotropic glutamate receptor 7 isoform b.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.471

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Network Stats

number of nodes:

8

number of edges:

14

average node degree:

3.5

avg. local clustering coefficient:

0.654

expected number of edges:

8

PPI enrichment p-value:

0.0243

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006626

Protein targeting to mitochondrion

8 of 46

2.55

7.4

8.00e-16

GO:0007005

Mitochondrion organization

10 of 344

1.78

4.38

1.68e-14

GO:0051204

Protein insertion into mitochondrial membrane

4 of 15

2.74

3.9

5.16e-08

GO:0030150

Protein import into mitochondrial matrix

4 of 22

2.57

3.56

1.79e-07

GO:0045040

Protein insertion into mitochondrial outer membrane

3 of 4

3.19

3.3

1.03e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

3 of 17

2.56

1.95

0.00025

GO:0030943

Mitochondrion targeting sequence binding

2 of 4

3.01

1.48

0.0021

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005742

Mitochondrial outer membrane translocase complex

11 of 19

3.08

15.21

3.37e-30

GO:0001401

SAM complex

4 of 5

3.22

5.19

3.32e-10

GO:0031307

Integral component of mitochondrial outer membrane

2 of 20

2.31

1.33

0.0033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28762

Outer mitochondrial membrane protein complex

11 of 17

3.12

15.26

4.92e-30

CL:28763

Outer mitochondrial membrane protein complex

9 of 12

3.19

12.42

4.29e-24

CL:28775

Outer mitochondrial membrane protein complex

5 of 6

3.23

6.27

3.26e-12

CL:28765

Outer mitochondrial membrane protein complex

4 of 5

3.22

4.72

2.46e-09

CL:28786

SAM complex, and MAS20 protein import receptor

2 of 5

2.91

1.43

0.0026

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5205685

PINK1-PRKN Mediated Mitophagy

7 of 25

2.76

7.48

3.06e-15

MAP-5205647

Mitophagy

7 of 44

2.51

6.54

5.25e-14

MAP-9663891

Selective autophagy

7 of 94

2.18

5.07

5.16e-12

MAP-9612973

Autophagy

7 of 163

1.95

4.01

1.60e-10

MAP-1632852

Macroautophagy

7 of 163

1.95

4.01

1.60e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098799

Outer mitochondrial membrane protein complex

8 of 15

3.04

10.21

4.36e-20

GOCC:0005742

Mitochondrial outer membrane translocase complex

7 of 11

3.12

9.25

5.12e-18

GOCC:0005741

Mitochondrial outer membrane

10 of 94

2.34

8.37

4.36e-20

GOCC:0001401

SAM complex

4 of 7

3.07

4.89

1.05e-09

GOCC:0005739

Mitochondrion

11 of 878

1.41

2.75

5.98e-14

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1000

Mitochondrion outer membrane

3 of 10

2.79

2.75

8.53e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17171

Glutathione S-transferase, C-terminal domain

2 of 5

2.91

1.12

0.0094

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