| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL10 | IL10RA | ENSCJAP00000034416 | ENSCJAP00000024017 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | Interleukin 10 receptor subunit alpha. | 0.999 |
| IL10 | IL22 | ENSCJAP00000034416 | ENSCJAP00000074107 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | Uncharacterized protein. | 0.989 |
| IL10 | TP53BP2 | ENSCJAP00000034416 | ENSCJAP00000076356 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | Tumor protein p53 binding protein 2. | 0.863 |
| IL10 | TYK2 | ENSCJAP00000034416 | ENSCJAP00000012623 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | Tyrosine-protein kinase. | 0.940 |
| IL10RA | IL10 | ENSCJAP00000024017 | ENSCJAP00000034416 | Interleukin 10 receptor subunit alpha. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.999 |
| IL10RA | IL22 | ENSCJAP00000024017 | ENSCJAP00000074107 | Interleukin 10 receptor subunit alpha. | Uncharacterized protein. | 0.795 |
| IL10RA | TP53BP2 | ENSCJAP00000024017 | ENSCJAP00000076356 | Interleukin 10 receptor subunit alpha. | Tumor protein p53 binding protein 2. | 0.863 |
| IL10RA | TYK2 | ENSCJAP00000024017 | ENSCJAP00000012623 | Interleukin 10 receptor subunit alpha. | Tyrosine-protein kinase. | 0.991 |
| IL22 | IL10 | ENSCJAP00000074107 | ENSCJAP00000034416 | Uncharacterized protein. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.989 |
| IL22 | IL10RA | ENSCJAP00000074107 | ENSCJAP00000024017 | Uncharacterized protein. | Interleukin 10 receptor subunit alpha. | 0.795 |
| IL22 | TP53BP2 | ENSCJAP00000074107 | ENSCJAP00000076356 | Uncharacterized protein. | Tumor protein p53 binding protein 2. | 0.919 |
| IL22 | TYK2 | ENSCJAP00000074107 | ENSCJAP00000012623 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.922 |
| LOC100410496 | PPP1CA | ENSCJAP00000029920 | ENSCJAP00000001692 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.995 |
| LOC100410496 | PPP1CB | ENSCJAP00000029920 | ENSCJAP00000055137 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.998 |
| LOC100410496 | PPP1CC | ENSCJAP00000029920 | ENSCJAP00000052805 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.900 |
| LOC100410496 | TP53BP2 | ENSCJAP00000029920 | ENSCJAP00000076356 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Tumor protein p53 binding protein 2. | 0.916 |
| LOC100410496 | WWTR1 | ENSCJAP00000029920 | ENSCJAP00000002354 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | WW domain-containing protein. | 0.926 |
| LOC100410496 | YAP1 | ENSCJAP00000029920 | ENSCJAP00000001114 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Yes associated protein 1. | 0.926 |
| PPP1CA | LOC100410496 | ENSCJAP00000001692 | ENSCJAP00000029920 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.995 |
| PPP1CA | PPP1CB | ENSCJAP00000001692 | ENSCJAP00000055137 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.998 |
