ENSCJAP00000077681 protein (Callithrix jacchus)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

ENSCJAP00000077681

Uncharacterized protein; Belongs to the complex I LYR family. (395 aa)

Predicted Functional Partners:

NFS1

0.959

NDUFAB1

0.835

ENSCJAP00000070238

0.788

FXN

0.788

ENSCJAP00000073407

0.788

ISCU

0.786

ENSCJAP00000071568

0.786

LOC100411089

0.786

ENSCJAP00000074164

0.786

FDX2

0.693

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCJAP00000070238	ENSCJAP00000071568	ENSCJAP00000070238	ENSCJAP00000071568	Uncharacterized protein.	NifU_N domain-containing protein.	0.772
ENSCJAP00000070238	ENSCJAP00000074164	ENSCJAP00000070238	ENSCJAP00000074164	Uncharacterized protein.	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000070238	ENSCJAP00000077681	ENSCJAP00000070238	ENSCJAP00000077681	Uncharacterized protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.788
ENSCJAP00000070238	FDX2	ENSCJAP00000070238	ENSCJAP00000067794	Uncharacterized protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.622
ENSCJAP00000070238	ISCU	ENSCJAP00000070238	ENSCJAP00000064225	Uncharacterized protein.	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform ISCU2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000070238	LOC100411089	ENSCJAP00000070238	ENSCJAP00000073885	Uncharacterized protein.	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000070238	NFS1	ENSCJAP00000070238	ENSCJAP00000032494	Uncharacterized protein.	Cysteine desulfurase, mitochondrial isoform a.	0.937
ENSCJAP00000071568	ENSCJAP00000070238	ENSCJAP00000071568	ENSCJAP00000070238	NifU_N domain-containing protein.	Uncharacterized protein.	0.772
ENSCJAP00000071568	ENSCJAP00000073407	ENSCJAP00000071568	ENSCJAP00000073407	NifU_N domain-containing protein.	Uncharacterized protein.	0.772
ENSCJAP00000071568	ENSCJAP00000077681	ENSCJAP00000071568	ENSCJAP00000077681	NifU_N domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.786
ENSCJAP00000071568	FDX2	ENSCJAP00000071568	ENSCJAP00000067794	NifU_N domain-containing protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.754
ENSCJAP00000071568	FXN	ENSCJAP00000071568	ENSCJAP00000073024	NifU_N domain-containing protein.	Frataxin, mitochondrial isoform 1 preproprotein.	0.772
ENSCJAP00000071568	NFS1	ENSCJAP00000071568	ENSCJAP00000032494	NifU_N domain-containing protein.	Cysteine desulfurase, mitochondrial isoform a.	0.976
ENSCJAP00000073407	ENSCJAP00000071568	ENSCJAP00000073407	ENSCJAP00000071568	Uncharacterized protein.	NifU_N domain-containing protein.	0.772
ENSCJAP00000073407	ENSCJAP00000074164	ENSCJAP00000073407	ENSCJAP00000074164	Uncharacterized protein.	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000073407	ENSCJAP00000077681	ENSCJAP00000073407	ENSCJAP00000077681	Uncharacterized protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.788
ENSCJAP00000073407	FDX2	ENSCJAP00000073407	ENSCJAP00000067794	Uncharacterized protein.	2Fe-2S ferredoxin-type domain-containing protein.	0.622
ENSCJAP00000073407	ISCU	ENSCJAP00000073407	ENSCJAP00000064225	Uncharacterized protein.	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial isoform ISCU2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000073407	LOC100411089	ENSCJAP00000073407	ENSCJAP00000073885	Uncharacterized protein.	NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.772
ENSCJAP00000073407	NFS1	ENSCJAP00000073407	ENSCJAP00000032494	Uncharacterized protein.	Cysteine desulfurase, mitochondrial isoform a.	0.937

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

9 of 181

1.98

4.96

1.46e-13

GO:0070202

Regulation of establishment of protein localization to chromosome

3 of 7

2.91

2.35

5.16e-05

GO:0051131

Chaperone-mediated protein complex assembly

3 of 14

2.61

2.02

0.00019

GO:0032212

Positive regulation of telomere maintenance via telomerase

3 of 15

2.58

2.01

0.00019

GO:1901998

Toxin transport

3 of 25

2.36

1.8

0.00042

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

8 of 32

2.68

8.25

3.58e-17

GO:0051082

Unfolded protein binding

9 of 99

2.24

6.82

1.30e-16

GO:0016887

ATP hydrolysis activity

8 of 313

1.69

3.24

2.88e-10

GO:0005524

ATP binding

10 of 1707

1.05

1.29

5.87e-08

GO:0005515

Protein binding

10 of 6721

0.45

0.34

0.0091

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005832

Chaperonin-containing T-complex

7 of 8

3.22

9.25

7.43e-18

GO:0005829

Cytosol

8 of 2661

0.76

0.57

0.0032

GO:0015630

Microtubule cytoskeleton

5 of 1109

0.93

0.49

0.0460

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:16454

TCP-1/cpn60 chaperonin family, and Protein FAM161A/B

11 of 13

3.21

15.74

1.24e-30

CL:16457

Chaperonin TCP-1, conserved site

8 of 8

3.28

11.24

1.41e-21

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

10 of 146

2.12

6.95

8.11e-19

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-390471

Association of TriC/CCT with target proteins during biosynthesis

9 of 19

2.96

11.15

2.88e-22

MAP-6814122

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

9 of 61

2.45

8.26

1.35e-18

MAP-390466

Chaperonin-mediated protein folding

9 of 75

2.36

7.74

5.09e-18

MAP-391251

Protein folding

9 of 80

2.33

7.6

6.58e-18

MAP-5620922

BBSome-mediated cargo-targeting to cilium

2 of 17

2.35

1.05

0.0118

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005832

Chaperonin-containing T-complex

8 of 9

3.23

10.84

6.50e-21

GOCC:0032991

Protein-containing complex

9 of 4409

0.59

0.41

0.0110

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

8 of 23

2.82

9.39

4.42e-19

KW-0963

Cytoplasm

7 of 292

1.66

2.9

5.55e-09

KW-0067

ATP-binding

8 of 888

1.24

1.65

1.67e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00118

TCP-1/cpn60 chaperonin family

10 of 13

3.17

13.82

6.25e-27

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027413

GroEL-like equatorial domain superfamily

9 of 11

3.19

12.01

2.85e-23

IPR027409

GroEL-like apical domain superfamily

9 of 12

3.16

11.97

2.85e-23

IPR002423

Chaperonin Cpn60/GroEL/TCP-1 family

9 of 12

3.16

11.97

2.85e-23

IPR017998

Chaperone tailless complex polypeptide 1 (TCP-1)

8 of 8

3.28

11.01

3.83e-21

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

8 of 9

3.23

10.87

5.78e-21

(more ...)

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