Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAP4K5Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (846 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 
 0.890
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.862
CRKL
CRK like proto-oncogene, adaptor protein.
    
 
 0.843
MAP4K3
Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
   
   0.682
MAP3K1
Mitogen-activated protein kinase kinase kinase 1.
   
 0.676
MAP3K11
Mitogen-activated protein kinase kinase kinase.
    
 0.661
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
      
 0.611
GRAP2
GRB2 related adaptor protein 2.
   
 
 0.567
LCP2
Lymphocyte cytosolic protein 2.
    
 
 0.563
KIDINS220
Kinase D interacting substrate 220.
    
 
 0.548
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
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