IL37 protein (Cebus capucinus) - STRING interaction network

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Score

IL37

Interleukin-1. (204 aa)

Predicted Functional Partners:

IL18R1

0.915

IL18

0.913

IL18RAP

0.886

IL18BP

0.862

IL1B

0.792

SMAD3

0.782

CASP1

0.721

JUND

0.687

IL1R1

0.687

IL1R2

0.657

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	IL18	ENSCCAP00000012722	ENSCCAP00000039638	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.968
CASP1	IL1B	ENSCCAP00000012722	ENSCCAP00000023501	Uncharacterized protein; Belongs to the peptidase C14A family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.997
CASP1	IL1R1	ENSCCAP00000012722	ENSCCAP00000040487	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin 1 receptor type 1.	0.559
CASP1	IL37	ENSCCAP00000012722	ENSCCAP00000001487	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1.	0.721
IL18	CASP1	ENSCCAP00000039638	ENSCCAP00000012722	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.968
IL18	IL18BP	ENSCCAP00000039638	ENSCCAP00000023942	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 binding protein.	0.918
IL18	IL18R1	ENSCCAP00000039638	ENSCCAP00000009070	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor 1.	0.956
IL18	IL18RAP	ENSCCAP00000039638	ENSCCAP00000025350	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 18 receptor accessory protein.	0.947
IL18	IL1B	ENSCCAP00000039638	ENSCCAP00000023501	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.864
IL18	IL1R1	ENSCCAP00000039638	ENSCCAP00000040487	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin 1 receptor type 1.	0.495
IL18	IL37	ENSCCAP00000039638	ENSCCAP00000001487	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-1.	0.913
IL18	JUND	ENSCCAP00000039638	ENSCCAP00000002419	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	JunD proto-oncogene, AP-1 transcription factor subunit.	0.869
IL18BP	IL18	ENSCCAP00000023942	ENSCCAP00000039638	Interleukin 18 binding protein.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.918
IL18BP	IL18R1	ENSCCAP00000023942	ENSCCAP00000009070	Interleukin 18 binding protein.	Interleukin 18 receptor 1.	0.717
IL18BP	IL18RAP	ENSCCAP00000023942	ENSCCAP00000025350	Interleukin 18 binding protein.	Interleukin 18 receptor accessory protein.	0.630
IL18BP	IL37	ENSCCAP00000023942	ENSCCAP00000001487	Interleukin 18 binding protein.	Interleukin-1.	0.862
IL18R1	IL18	ENSCCAP00000009070	ENSCCAP00000039638	Interleukin 18 receptor 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.956
IL18R1	IL18BP	ENSCCAP00000009070	ENSCCAP00000023942	Interleukin 18 receptor 1.	Interleukin 18 binding protein.	0.717
IL18R1	IL18RAP	ENSCCAP00000009070	ENSCCAP00000025350	Interleukin 18 receptor 1.	Interleukin 18 receptor accessory protein.	0.995
IL18R1	IL1B	ENSCCAP00000009070	ENSCCAP00000023501	Interleukin 18 receptor 1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.608