H2AX protein (Cebus capucinus) - STRING interaction network

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[Homology]

Score

H2AX

Histone H2A; Belongs to the histone H2A family. (143 aa)

Predicted Functional Partners:

H2BC3

0.944

H2BC18

0.944

H2AC20

0.940

ENSCCAP00000025584

0.940

H2AJ

0.928

LOC108298786

0.913

H2AC7

0.908

HDAC2

0.908

BRCA1

0.900

ENSCCAP00000019138

0.897

Your Current Organism:

Cebus capucinus

NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	ENSCCAP00000019138	ENSCCAP00000017232	ENSCCAP00000019138	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAWUL domain-containing protein.	0.742
BRCA1	ENSCCAP00000025584	ENSCCAP00000017232	ENSCCAP00000025584	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2A; Belongs to the histone H2A family.	0.839
BRCA1	H2AC20	ENSCCAP00000017232	ENSCCAP00000001016	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2A; Belongs to the histone H2A family.	0.922
BRCA1	H2AC7	ENSCCAP00000017232	ENSCCAP00000002337	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2A; Belongs to the histone H2A family.	0.782
BRCA1	H2AJ	ENSCCAP00000017232	ENSCCAP00000004067	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2A; Belongs to the histone H2A family.	0.839
BRCA1	H2AX	ENSCCAP00000017232	ENSCCAP00000001925	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2A; Belongs to the histone H2A family.	0.900
BRCA1	H2BC3	ENSCCAP00000017232	ENSCCAP00000002616	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone H2B; Belongs to the histone H2B family.	0.705
BRCA1	HDAC2	ENSCCAP00000017232	ENSCCAP00000035632	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.795
ENSCCAP00000019138	BRCA1	ENSCCAP00000019138	ENSCCAP00000017232	RAWUL domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.742
ENSCCAP00000019138	ENSCCAP00000025584	ENSCCAP00000019138	ENSCCAP00000025584	RAWUL domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.810
ENSCCAP00000019138	H2AC20	ENSCCAP00000019138	ENSCCAP00000001016	RAWUL domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.920
ENSCCAP00000019138	H2AC7	ENSCCAP00000019138	ENSCCAP00000002337	RAWUL domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.787
ENSCCAP00000019138	H2AJ	ENSCCAP00000019138	ENSCCAP00000004067	RAWUL domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.813
ENSCCAP00000019138	H2AX	ENSCCAP00000019138	ENSCCAP00000001925	RAWUL domain-containing protein.	Histone H2A; Belongs to the histone H2A family.	0.897
ENSCCAP00000019138	H2BC18	ENSCCAP00000019138	ENSCCAP00000036822	RAWUL domain-containing protein.	Histone H2B; Belongs to the histone H2B family.	0.767
ENSCCAP00000019138	H2BC3	ENSCCAP00000019138	ENSCCAP00000002616	RAWUL domain-containing protein.	Histone H2B; Belongs to the histone H2B family.	0.785
ENSCCAP00000019138	HDAC2	ENSCCAP00000019138	ENSCCAP00000035632	RAWUL domain-containing protein.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.882
ENSCCAP00000019138	LOC108298786	ENSCCAP00000019138	ENSCCAP00000027161	RAWUL domain-containing protein.	Histone H2B; Belongs to the histone H2B family.	0.672
ENSCCAP00000025584	BRCA1	ENSCCAP00000025584	ENSCCAP00000017232	Histone H2A; Belongs to the histone H2A family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.839
ENSCCAP00000025584	ENSCCAP00000019138	ENSCCAP00000025584	ENSCCAP00000019138	Histone H2A; Belongs to the histone H2A family.	RAWUL domain-containing protein.	0.810