STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)    
Predicted Functional Partners:
BIRC6
Baculoviral IAP repeat containing 6.
   
 
 0.900
ZRANB1
Zinc finger RANBP2-type containing 1.
   
 
 0.881
TRIP12
Thyroid hormone receptor interactor 12.
   
 
 0.855
ZNF622
Zinc finger protein 622.
    
 
 0.832
URGCP
Upregulator of cell proliferation.
    
   0.817
COPA
Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.
   
   0.790
SMC2
Structural maintenance of chromosomes protein.
   
   0.779
IQGAP1
IQ motif containing GTPase activating protein 1.
    
   0.778
SMC4
Structural maintenance of chromosomes protein.
   
   0.774
ENSCCAP00000004912
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.763
Your Current Organism:
Cebus capucinus
NCBI taxonomy Id: 9516
Other names: C. capucinus, white-faced capuchin, white-faced sapajou, white-throated capuchin
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.