node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS32306.1 | fhs | SAMN05660874_00204 | SAMN05660874_00206 | Aminomethyltransferase; Belongs to the GcvT family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.955 |
SFS32306.1 | folD | SAMN05660874_00204 | SAMN05660874_00995 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.835 |
SFS32306.1 | gcvP | SAMN05660874_00204 | SAMN05660874_04958 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.998 |
SFS32306.1 | gcvT | SAMN05660874_00204 | SAMN05660874_00253 | Aminomethyltransferase; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.832 |
SFS32306.1 | glyA | SAMN05660874_00204 | SAMN05660874_00254 | Aminomethyltransferase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
SFS32306.1 | purH | SAMN05660874_00204 | SAMN05660874_01005 | Aminomethyltransferase; Belongs to the GcvT family. | IMP cyclohydrolase. | 0.872 |
SFS32306.1 | purN | SAMN05660874_00204 | SAMN05660874_01006 | Aminomethyltransferase; Belongs to the GcvT family. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.862 |
SFS39606.1 | SFS51806.1 | SAMN05660874_00785 | SAMN05660874_01454 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.821 |
SFS39606.1 | gcvP | SAMN05660874_00785 | SAMN05660874_04958 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.707 |
SFS39606.1 | glyA | SAMN05660874_00785 | SAMN05660874_00254 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
SFS51806.1 | SFS39606.1 | SAMN05660874_01454 | SAMN05660874_00785 | Phosphoserine phosphatase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.821 |
SFS51806.1 | gcvP | SAMN05660874_01454 | SAMN05660874_04958 | Phosphoserine phosphatase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.406 |
SFS51806.1 | glyA | SAMN05660874_01454 | SAMN05660874_00254 | Phosphoserine phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
SFS98793.1 | fhs | SAMN05660874_04737 | SAMN05660874_00206 | Ribose 5-phosphate isomerase B. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.464 |
SFS98793.1 | folD | SAMN05660874_04737 | SAMN05660874_00995 | Ribose 5-phosphate isomerase B. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.529 |
SFS98793.1 | gcvP | SAMN05660874_04737 | SAMN05660874_04958 | Ribose 5-phosphate isomerase B. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.797 |
SFS98793.1 | glyA | SAMN05660874_04737 | SAMN05660874_00254 | Ribose 5-phosphate isomerase B. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
SFS98793.1 | purN | SAMN05660874_04737 | SAMN05660874_01006 | Ribose 5-phosphate isomerase B. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.435 |
fhs | SFS32306.1 | SAMN05660874_00206 | SAMN05660874_00204 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.955 |
fhs | SFS98793.1 | SAMN05660874_00206 | SAMN05660874_04737 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Ribose 5-phosphate isomerase B. | 0.464 |