node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS57288.1 | SFS66847.1 | SAMN05660874_02076 | SAMN05660874_02498 | DNA polymerase III, delta prime subunit. | ATP-dependent DNA ligase. | 0.806 |
SFS57288.1 | SFS70258.1 | SAMN05660874_02076 | SAMN05660874_02767 | DNA polymerase III, delta prime subunit. | 5'-3' exonuclease. | 0.882 |
SFS57288.1 | SFS84965.1 | SAMN05660874_02076 | SAMN05660874_03716 | DNA polymerase III, delta prime subunit. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.996 |
SFS57288.1 | ligA | SAMN05660874_02076 | SAMN05660874_00625 | DNA polymerase III, delta prime subunit. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.628 |
SFS57288.1 | polA | SAMN05660874_02076 | SAMN05660874_02301 | DNA polymerase III, delta prime subunit. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.974 |
SFS63069.1 | SFS66847.1 | SAMN05660874_02134 | SAMN05660874_02498 | DNA ligase D. | ATP-dependent DNA ligase. | 0.968 |
SFS63069.1 | SFS77681.1 | SAMN05660874_02134 | SAMN05660874_03194 | DNA ligase D. | Bifunctional non-homologous end joining protein LigD. | 0.765 |
SFS63069.1 | SFT05224.1 | SAMN05660874_02134 | SAMN05660874_05294 | DNA ligase D. | Bifunctional non-homologous end joining protein LigD. | 0.752 |
SFS63069.1 | ku | SAMN05660874_02134 | SAMN05660874_03550 | DNA ligase D. | DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.890 |
SFS66822.1 | SFS66847.1 | SAMN05660874_02495 | SAMN05660874_02498 | Uncharacterized conserved protein YloU, alkaline shock protein (Asp23) family. | ATP-dependent DNA ligase. | 0.799 |
SFS66847.1 | SFS57288.1 | SAMN05660874_02498 | SAMN05660874_02076 | ATP-dependent DNA ligase. | DNA polymerase III, delta prime subunit. | 0.806 |
SFS66847.1 | SFS63069.1 | SAMN05660874_02498 | SAMN05660874_02134 | ATP-dependent DNA ligase. | DNA ligase D. | 0.968 |
SFS66847.1 | SFS66822.1 | SAMN05660874_02498 | SAMN05660874_02495 | ATP-dependent DNA ligase. | Uncharacterized conserved protein YloU, alkaline shock protein (Asp23) family. | 0.799 |
SFS66847.1 | SFS70258.1 | SAMN05660874_02498 | SAMN05660874_02767 | ATP-dependent DNA ligase. | 5'-3' exonuclease. | 0.915 |
SFS66847.1 | SFS77681.1 | SAMN05660874_02498 | SAMN05660874_03194 | ATP-dependent DNA ligase. | Bifunctional non-homologous end joining protein LigD. | 0.961 |
SFS66847.1 | SFS84965.1 | SAMN05660874_02498 | SAMN05660874_03716 | ATP-dependent DNA ligase. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.971 |
SFS66847.1 | SFT05224.1 | SAMN05660874_02498 | SAMN05660874_05294 | ATP-dependent DNA ligase. | Bifunctional non-homologous end joining protein LigD. | 0.906 |
SFS66847.1 | ku | SAMN05660874_02498 | SAMN05660874_03550 | ATP-dependent DNA ligase. | DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.935 |
SFS66847.1 | ligA | SAMN05660874_02498 | SAMN05660874_00625 | ATP-dependent DNA ligase. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.828 |
SFS66847.1 | polA | SAMN05660874_02498 | SAMN05660874_02301 | ATP-dependent DNA ligase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.914 |