node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS32290.1 | SFS32306.1 | SAMN05660874_00203 | SAMN05660874_00204 | Dimethylglycine oxidase; Belongs to the GcvT family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.930 |
SFS32290.1 | SFS89526.1 | SAMN05660874_00203 | SAMN05660874_04012 | Dimethylglycine oxidase; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.814 |
SFS32290.1 | SFS89559.1 | SAMN05660874_00203 | SAMN05660874_04015 | Dimethylglycine oxidase; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.995 |
SFS32290.1 | SFS89588.1 | SAMN05660874_00203 | SAMN05660874_04018 | Dimethylglycine oxidase; Belongs to the GcvT family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.992 |
SFS32290.1 | SFT05662.1 | SAMN05660874_00203 | SAMN05660874_05348 | Dimethylglycine oxidase; Belongs to the GcvT family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.939 |
SFS32290.1 | folD | SAMN05660874_00203 | SAMN05660874_00995 | Dimethylglycine oxidase; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.867 |
SFS32290.1 | gcvT | SAMN05660874_00203 | SAMN05660874_00253 | Dimethylglycine oxidase; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.851 |
SFS32290.1 | glyA | SAMN05660874_00203 | SAMN05660874_00254 | Dimethylglycine oxidase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
SFS32290.1 | thyX | SAMN05660874_00203 | SAMN05660874_00392 | Dimethylglycine oxidase; Belongs to the GcvT family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.625 |
SFS32306.1 | SFS32290.1 | SAMN05660874_00204 | SAMN05660874_00203 | Aminomethyltransferase; Belongs to the GcvT family. | Dimethylglycine oxidase; Belongs to the GcvT family. | 0.930 |
SFS32306.1 | SFS89526.1 | SAMN05660874_00204 | SAMN05660874_04012 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | 0.820 |
SFS32306.1 | SFS89559.1 | SAMN05660874_00204 | SAMN05660874_04015 | Aminomethyltransferase; Belongs to the GcvT family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.605 |
SFS32306.1 | SFS89588.1 | SAMN05660874_00204 | SAMN05660874_04018 | Aminomethyltransferase; Belongs to the GcvT family. | Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.857 |
SFS32306.1 | SFT05662.1 | SAMN05660874_00204 | SAMN05660874_05348 | Aminomethyltransferase; Belongs to the GcvT family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.869 |
SFS32306.1 | folD | SAMN05660874_00204 | SAMN05660874_00995 | Aminomethyltransferase; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.835 |
SFS32306.1 | gcvT | SAMN05660874_00204 | SAMN05660874_00253 | Aminomethyltransferase; Belongs to the GcvT family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.832 |
SFS32306.1 | glyA | SAMN05660874_00204 | SAMN05660874_00254 | Aminomethyltransferase; Belongs to the GcvT family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.934 |
SFS32306.1 | thyX | SAMN05660874_00204 | SAMN05660874_00392 | Aminomethyltransferase; Belongs to the GcvT family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.807 |
SFS89526.1 | SFS32290.1 | SAMN05660874_04012 | SAMN05660874_00203 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Dimethylglycine oxidase; Belongs to the GcvT family. | 0.814 |
SFS89526.1 | SFS32306.1 | SAMN05660874_04012 | SAMN05660874_00204 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; Belongs to the GcvT family. | 0.820 |