node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFS43396.1 | SFS99581.1 | SAMN05660874_01084 | SAMN05660874_04821 | Malate synthase; Belongs to the malate synthase family. | Aspartate aminotransferase. | 0.780 |
SFS43396.1 | SFT06356.1 | SAMN05660874_01084 | SAMN05660874_05371 | Malate synthase; Belongs to the malate synthase family. | Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.860 |
SFS43396.1 | gcvP | SAMN05660874_01084 | SAMN05660874_04958 | Malate synthase; Belongs to the malate synthase family. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.480 |
SFS51806.1 | SFS54792.1 | SAMN05660874_01454 | SAMN05660874_01719 | Phosphoserine phosphatase. | Cystathionine beta-synthase. | 0.911 |
SFS51806.1 | SFS99581.1 | SAMN05660874_01454 | SAMN05660874_04821 | Phosphoserine phosphatase. | Aspartate aminotransferase. | 0.771 |
SFS51806.1 | SFT05662.1 | SAMN05660874_01454 | SAMN05660874_05348 | Phosphoserine phosphatase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.824 |
SFS51806.1 | gcvP | SAMN05660874_01454 | SAMN05660874_04958 | Phosphoserine phosphatase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.406 |
SFS51806.1 | glyA | SAMN05660874_01454 | SAMN05660874_00254 | Phosphoserine phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
SFS54792.1 | SFS51806.1 | SAMN05660874_01719 | SAMN05660874_01454 | Cystathionine beta-synthase. | Phosphoserine phosphatase. | 0.911 |
SFS54792.1 | SFS86975.1 | SAMN05660874_01719 | SAMN05660874_03882 | Cystathionine beta-synthase. | Aspartate/methionine/tyrosine aminotransferase. | 0.736 |
SFS54792.1 | SFS99581.1 | SAMN05660874_01719 | SAMN05660874_04821 | Cystathionine beta-synthase. | Aspartate aminotransferase. | 0.753 |
SFS54792.1 | SFT05662.1 | SAMN05660874_01719 | SAMN05660874_05348 | Cystathionine beta-synthase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.914 |
SFS54792.1 | glyA | SAMN05660874_01719 | SAMN05660874_00254 | Cystathionine beta-synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.898 |
SFS86975.1 | SFS54792.1 | SAMN05660874_03882 | SAMN05660874_01719 | Aspartate/methionine/tyrosine aminotransferase. | Cystathionine beta-synthase. | 0.736 |
SFS86975.1 | SFS87009.1 | SAMN05660874_03882 | SAMN05660874_03885 | Aspartate/methionine/tyrosine aminotransferase. | L-threonine aldolase. | 0.600 |
SFS86975.1 | SFS99581.1 | SAMN05660874_03882 | SAMN05660874_04821 | Aspartate/methionine/tyrosine aminotransferase. | Aspartate aminotransferase. | 0.761 |
SFS86975.1 | SFT05662.1 | SAMN05660874_03882 | SAMN05660874_05348 | Aspartate/methionine/tyrosine aminotransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.816 |
SFS86975.1 | SFT06356.1 | SAMN05660874_03882 | SAMN05660874_05371 | Aspartate/methionine/tyrosine aminotransferase. | Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.537 |
SFS86975.1 | gcvP | SAMN05660874_03882 | SAMN05660874_04958 | Aspartate/methionine/tyrosine aminotransferase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.809 |
SFS86975.1 | glyA | SAMN05660874_03882 | SAMN05660874_00254 | Aspartate/methionine/tyrosine aminotransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.444 |