node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDU88442.1 | SDV00801.1 | SAMN05216558_0272 | SAMN05216558_1758 | Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like/2,3-diketo-5-methylthio-1-phosphopentane phosphatase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.463 |
SDU88442.1 | SDV13256.1 | SAMN05216558_0272 | SAMN05216558_3827 | Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like/2,3-diketo-5-methylthio-1-phosphopentane phosphatase. | L-fuculose-phosphate aldolase. | 0.516 |
SDU88442.1 | mtnD | SAMN05216558_0272 | SAMN05216558_0958 | Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like/2,3-diketo-5-methylthio-1-phosphopentane phosphatase. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.956 |
SDU89815.1 | SDV00801.1 | SAMN05216558_0423 | SAMN05216558_1758 | Z1 domain-containing protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.629 |
SDU89815.1 | SDV13256.1 | SAMN05216558_0423 | SAMN05216558_3827 | Z1 domain-containing protein. | L-fuculose-phosphate aldolase. | 0.511 |
SDU89815.1 | fba | SAMN05216558_0423 | SAMN05216558_5502 | Z1 domain-containing protein. | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | 0.814 |
SDV00801.1 | SDU88442.1 | SAMN05216558_1758 | SAMN05216558_0272 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like/2,3-diketo-5-methylthio-1-phosphopentane phosphatase. | 0.463 |
SDV00801.1 | SDU89815.1 | SAMN05216558_1758 | SAMN05216558_0423 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Z1 domain-containing protein. | 0.629 |
SDV00801.1 | SDV13254.1 | SAMN05216558_1758 | SAMN05216558_3826 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Transcriptional regulator, XRE family with cupin sensor. | 0.699 |
SDV00801.1 | SDV13256.1 | SAMN05216558_1758 | SAMN05216558_3827 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-fuculose-phosphate aldolase. | 0.503 |
SDV00801.1 | mtnA | SAMN05216558_1758 | SAMN05216558_0711 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.834 |
SDV00801.1 | mtnD | SAMN05216558_1758 | SAMN05216558_0958 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acireductone dioxygenase apoprotein; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.772 |
SDV13254.1 | SDV00801.1 | SAMN05216558_3826 | SAMN05216558_1758 | Transcriptional regulator, XRE family with cupin sensor. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.699 |
SDV13254.1 | SDV13256.1 | SAMN05216558_3826 | SAMN05216558_3827 | Transcriptional regulator, XRE family with cupin sensor. | L-fuculose-phosphate aldolase. | 0.664 |
SDV13254.1 | SDV13258.1 | SAMN05216558_3826 | SAMN05216558_3828 | Transcriptional regulator, XRE family with cupin sensor. | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. | 0.660 |
SDV13254.1 | tpiA | SAMN05216558_3826 | SAMN05216558_4382 | Transcriptional regulator, XRE family with cupin sensor. | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.438 |
SDV13256.1 | SDU88442.1 | SAMN05216558_3827 | SAMN05216558_0272 | L-fuculose-phosphate aldolase. | Haloacid Dehalogenase superfamily, subfamily IB, phosphoserine phosphatase-like/2,3-diketo-5-methylthio-1-phosphopentane phosphatase. | 0.516 |
SDV13256.1 | SDU89815.1 | SAMN05216558_3827 | SAMN05216558_0423 | L-fuculose-phosphate aldolase. | Z1 domain-containing protein. | 0.511 |
SDV13256.1 | SDV00801.1 | SAMN05216558_3827 | SAMN05216558_1758 | L-fuculose-phosphate aldolase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.503 |
SDV13256.1 | SDV13254.1 | SAMN05216558_3827 | SAMN05216558_3826 | L-fuculose-phosphate aldolase. | Transcriptional regulator, XRE family with cupin sensor. | 0.664 |