DYRK3 protein (Cercocebus atys) - STRING interaction network

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Score

DYRK3

Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)

Predicted Functional Partners:

DCAF7

0.778

TP53

0.664

ATM

0.638

UNC119

0.609

CCNL1

0.489

PIN1

0.470

DCAF1

0.462

PLK2

0.443

PLK5

0.443

PLK3

0.443

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DYRK3	ENSCATP00000032722	ENSCATP00000001329	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.638
ATM	TP53	ENSCATP00000032722	ENSCATP00000032045	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
CCNL1	DCAF1	ENSCATP00000023706	ENSCATP00000003704	Cyclin L1; Belongs to the cyclin family.	DDB1 and CUL4 associated factor 1.	0.408
CCNL1	DYRK3	ENSCATP00000023706	ENSCATP00000001329	Cyclin L1; Belongs to the cyclin family.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.489
DCAF1	CCNL1	ENSCATP00000003704	ENSCATP00000023706	DDB1 and CUL4 associated factor 1.	Cyclin L1; Belongs to the cyclin family.	0.408
DCAF1	DYRK3	ENSCATP00000003704	ENSCATP00000001329	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.462
DCAF7	DYRK3	ENSCATP00000031032	ENSCATP00000001329	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.778
DYRK3	ATM	ENSCATP00000001329	ENSCATP00000032722	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.638
DYRK3	CCNL1	ENSCATP00000001329	ENSCATP00000023706	Dual specificity tyrosine phosphorylation regulated kinase 3.	Cyclin L1; Belongs to the cyclin family.	0.489
DYRK3	DCAF1	ENSCATP00000001329	ENSCATP00000003704	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 1.	0.462
DYRK3	DCAF7	ENSCATP00000001329	ENSCATP00000031032	Dual specificity tyrosine phosphorylation regulated kinase 3.	DDB1 and CUL4 associated factor 7.	0.778
DYRK3	PIN1	ENSCATP00000001329	ENSCATP00000042760	Dual specificity tyrosine phosphorylation regulated kinase 3.	Peptidyl-prolyl cis-trans isomerase.	0.470
DYRK3	PLK2	ENSCATP00000001329	ENSCATP00000013693	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine/threonine-protein kinase PLK.	0.443
DYRK3	PLK3	ENSCATP00000001329	ENSCATP00000037601	Dual specificity tyrosine phosphorylation regulated kinase 3.	Serine/threonine-protein kinase PLK.	0.443
DYRK3	PLK5	ENSCATP00000001329	ENSCATP00000015290	Dual specificity tyrosine phosphorylation regulated kinase 3.	Polo like kinase 5.	0.443
DYRK3	TP53	ENSCATP00000001329	ENSCATP00000032045	Dual specificity tyrosine phosphorylation regulated kinase 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.664
DYRK3	UNC119	ENSCATP00000001329	ENSCATP00000018690	Dual specificity tyrosine phosphorylation regulated kinase 3.	Unc-119 lipid binding chaperone.	0.609
PIN1	DYRK3	ENSCATP00000042760	ENSCATP00000001329	Peptidyl-prolyl cis-trans isomerase.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.470
PIN1	TP53	ENSCATP00000042760	ENSCATP00000032045	Peptidyl-prolyl cis-trans isomerase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.857
PLK2	DYRK3	ENSCATP00000013693	ENSCATP00000001329	Serine/threonine-protein kinase PLK.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.443