DYRK3 protein (Cercocebus atys) - STRING interaction network

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Score

DYRK3

Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)

Predicted Functional Partners:

TP53

0.821

ATM

0.771

DCAF1

0.729

DCAF7

0.686

UBR5

0.643

DDB1

0.640

MDM2

0.554

PNRC1

0.549

ENSCATP00000000090

0.546

CEP78

0.510

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DYRK3	ENSCATP00000032722	ENSCATP00000001329	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.771
ATM	ENSCATP00000000090	ENSCATP00000032722	ENSCATP00000000090	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.944
ATM	MDM2	ENSCATP00000032722	ENSCATP00000045842	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.979
ATM	TP53	ENSCATP00000032722	ENSCATP00000032045	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
CEP78	DCAF1	ENSCATP00000027077	ENSCATP00000003704	Centrosomal protein 78.	DDB1 and CUL4 associated factor 1.	0.808
CEP78	DDB1	ENSCATP00000027077	ENSCATP00000044056	Centrosomal protein 78.	Damage specific DNA binding protein 1.	0.838
CEP78	DYRK3	ENSCATP00000027077	ENSCATP00000001329	Centrosomal protein 78.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.510
CEP78	UBR5	ENSCATP00000027077	ENSCATP00000024987	Centrosomal protein 78.	Ubiquitin protein ligase E3 component n-recognin 5.	0.808
DCAF1	CEP78	ENSCATP00000003704	ENSCATP00000027077	DDB1 and CUL4 associated factor 1.	Centrosomal protein 78.	0.808
DCAF1	DDB1	ENSCATP00000003704	ENSCATP00000044056	DDB1 and CUL4 associated factor 1.	Damage specific DNA binding protein 1.	0.996
DCAF1	DYRK3	ENSCATP00000003704	ENSCATP00000001329	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.729
DCAF1	TP53	ENSCATP00000003704	ENSCATP00000032045	DDB1 and CUL4 associated factor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.654
DCAF1	UBR5	ENSCATP00000003704	ENSCATP00000024987	DDB1 and CUL4 associated factor 1.	Ubiquitin protein ligase E3 component n-recognin 5.	0.459
DCAF7	DDB1	ENSCATP00000031032	ENSCATP00000044056	DDB1 and CUL4 associated factor 7.	Damage specific DNA binding protein 1.	0.975
DCAF7	DYRK3	ENSCATP00000031032	ENSCATP00000001329	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.686
DDB1	CEP78	ENSCATP00000044056	ENSCATP00000027077	Damage specific DNA binding protein 1.	Centrosomal protein 78.	0.838
DDB1	DCAF1	ENSCATP00000044056	ENSCATP00000003704	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 1.	0.996
DDB1	DCAF7	ENSCATP00000044056	ENSCATP00000031032	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 7.	0.975
DDB1	DYRK3	ENSCATP00000044056	ENSCATP00000001329	Damage specific DNA binding protein 1.	Dual specificity tyrosine phosphorylation regulated kinase 3.	0.640
DDB1	ENSCATP00000000090	ENSCATP00000044056	ENSCATP00000000090	Damage specific DNA binding protein 1.	Uncharacterized protein.	0.537