Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
WDR45Uncharacterized protein. (360 aa)    
Predicted Functional Partners:
ATG2A
Autophagy related 2A.
    
 0.992
ATG2B
Autophagy related 2B.
    
 0.992
ATG16L1
Autophagy related 16 like 1.
     
 0.926
ATG16L2
Autophagy related 16 like 2.
     
 0.926
LHX6
LIM homeobox 6.
    
   0.786
HDAC11
Histone deacetylase 11.
    
   0.669
TALDO1
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
    
   0.651
OTUD7B
OTU deubiquitinase 7B.
      
 0.560
ATG7
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]
    
 
 0.531
BECN1
Beclin 1.
    
 
 0.500
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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