Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PARP2Poly [ADP-ribose] polymerase. (581 aa)    
Predicted Functional Partners:
PARG
Poly(ADP-ribose) glycohydrolase.
    
 0.963
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 0.956
POLB
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
    
 0.944
CASP9
Caspase 9; Belongs to the peptidase C14A family.
    
 0.940
CASP7
Caspase 7; Belongs to the peptidase C14A family.
    
 0.937
CASP3
Uncharacterized protein; Belongs to the peptidase C14A family.
    
 0.937
APLF
Aprataxin and PNKP like factor.
    
 
 0.936
XPC
XPC complex subunit, DNA damage recognition and repair factor.
    
 0.933
RNF146
Ring finger protein 146.
    
 
 0.927
LIG3
DNA ligase.
   
 
 0.924
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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