Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)    
Predicted Functional Partners:
HEY2
Hes related family bHLH transcription factor with YRPW motif 2.
    
 
0.991
HEYL
Hes related family bHLH transcription factor with YRPW motif like.
  
  
 
0.922
NOTCH1
Notch receptor 1.
    
 0.872
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.853
NOTCH3
Notch receptor 3.
    
 0.810
NOTCH4
Notch receptor 4.
   
 0.805
HES4
Hes family bHLH transcription factor 4.
    
 0.777
HES1
Hes family bHLH transcription factor 1.
    
 0.777
NOTCH2
Notch receptor 2.
    
 0.775
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.690
Your Current Organism:
Cercocebus atys
NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey
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