SERINC4 protein (Cercocebus atys) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

SERINC4

Serine incorporator 4. (519 aa)

Predicted Functional Partners:

BST2

0.856

ELL3

0.785

ENSCATP00000019442

0.712

TRIM5

0.619

CPA5

0.601

NEMF

0.586

TRAF6

0.578

CD4

0.500

GTF3C5

0.499

NUS1

0.491

Your Current Organism:

Cercocebus atys

NCBI taxonomy Id: 9531
Other names: C. atys, Cercocebus torquatus atys, sooty mangabey

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BST2	CD4	ENSCATP00000039417	ENSCATP00000030139	Bone marrow stromal cell antigen 2.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.631
BST2	SERINC4	ENSCATP00000039417	ENSCATP00000001732	Bone marrow stromal cell antigen 2.	Serine incorporator 4.	0.856
BST2	TRIM5	ENSCATP00000039417	ENSCATP00000021783	Bone marrow stromal cell antigen 2.	Tripartite motif-containing 5 alpha isoform.	0.498
CD4	BST2	ENSCATP00000030139	ENSCATP00000039417	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Bone marrow stromal cell antigen 2.	0.631
CD4	ENSCATP00000019442	ENSCATP00000030139	ENSCATP00000019442	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Uncharacterized protein.	0.599
CD4	SERINC4	ENSCATP00000030139	ENSCATP00000001732	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Serine incorporator 4.	0.500
CD4	TRAF6	ENSCATP00000030139	ENSCATP00000012971	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.696
CD4	TRIM5	ENSCATP00000030139	ENSCATP00000021783	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Tripartite motif-containing 5 alpha isoform.	0.765
CPA5	NEMF	ENSCATP00000019485	ENSCATP00000021815	Carboxypeptidase A5.	Nuclear export mediator factor.	0.453
CPA5	SERINC4	ENSCATP00000019485	ENSCATP00000001732	Carboxypeptidase A5.	Serine incorporator 4.	0.601
ELL3	SERINC4	ENSCATP00000039969	ENSCATP00000001732	Elongation factor for RNA polymerase II 3.	Serine incorporator 4.	0.785
ENSCATP00000019442	CD4	ENSCATP00000019442	ENSCATP00000030139	Uncharacterized protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.599
ENSCATP00000019442	SERINC4	ENSCATP00000019442	ENSCATP00000001732	Uncharacterized protein.	Serine incorporator 4.	0.712
ENSCATP00000019442	TRIM5	ENSCATP00000019442	ENSCATP00000021783	Uncharacterized protein.	Tripartite motif-containing 5 alpha isoform.	0.690
GTF3C5	SERINC4	ENSCATP00000011293	ENSCATP00000001732	General transcription factor IIIC subunit 5.	Serine incorporator 4.	0.499
NEMF	CPA5	ENSCATP00000021815	ENSCATP00000019485	Nuclear export mediator factor.	Carboxypeptidase A5.	0.453
NEMF	SERINC4	ENSCATP00000021815	ENSCATP00000001732	Nuclear export mediator factor.	Serine incorporator 4.	0.586
NUS1	SERINC4	ENSCATP00000032012	ENSCATP00000001732	NUS1 dehydrodolichyl diphosphate synthase subunit.	Serine incorporator 4.	0.491
SERINC4	BST2	ENSCATP00000001732	ENSCATP00000039417	Serine incorporator 4.	Bone marrow stromal cell antigen 2.	0.856
SERINC4	CD4	ENSCATP00000001732	ENSCATP00000030139	Serine incorporator 4.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.500